2. Stem Cell/Wnt
  3. Hippo (MST)
  4. MR24

MR24 是 G-5555 (HY-19635) 的衍生物，是一种哺乳动物 STE20 样 (MST) 激酶抑制剂。MR24 对 MST3/4 的选择性显著高于 MST1/2，其 EC50 值分别为 57 nM 和 583 nM。MR24 可诱导 G1 期细胞周期阻滞。MR24 可用于癌症研究，例如乳腺癌、肝癌和肺癌。

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MR24

MR24 Chemical Structure

CAS No. : 3056814-89-9

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MR24 相关抗体

Top Publications Citing Use of Products

查看 Hippo (MST) 亚型特异性产品:

查看所有亚型
MST1 MST2 MST3 MST4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers[1].

IC50 & Target[1]

MST3

57 nM (EC50)

MST4

583 nM (EC50)

体外研究
(In Vitro)

MR24 (compound 24) (1-10 μM, 6-72 小时) 对 HCT116 细胞的健康细胞核无显著影响，仅在 10 μM 浓度下导致细胞活力略微下降约 30%[1]。
MR24 (1-10 μM, 24-72 小时) 可诱导 HCT116 细胞发生 G1 期细胞周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MR24 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 1, 5, and 10 μM
Incubation Time: 24, 48 and 72 h
Result: Increased the fraction of cells in the G1 phase at 10 μM.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 1 and 10 μM
Incubation Time: 6, 12, 24, 48 and 72 h
Result: Showed no significant effect on the normalized cell count at a concentration of 1 μM.
Resulted in a slight reduction in cell viability by about 30% at a concentration of 10 μM.
Resulted in over 90% healthy nuclei after 24 h at both concentrations used (1 and 10 μM).
分子量

509.00

Formula

C26H29ClN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MR24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR243056814-89-9MR 24MR-24Hippo (MST)MST3/4breast cancerliver cancerlung cancerHippoHCT116Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-157932
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