2. Metabolic Enzyme/Protease
  3. PAI-1
  4. Anecortave acetate

Anecortave acetate  (Synonyms: Anecortave)

目录号: HY-116868 纯度: ≥99.0%
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Anecortave acetate 是一种有效的眼部血管抑制剂。Anecortave acetate 抑制由许多不同的血管生成因子诱导的新血管形成，也能增加纤溶酶原激活物抑制子 1 (PAI-1) mRNA表达。Anecortave acetate 可用于研究眼部新生血管疾病。

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Anecortave acetate Chemical Structure

Anecortave acetate Chemical Structure

CAS No. : 7753-60-8

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5 mg ￥2030
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10 mg ￥3147
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Anecortave acetate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].

IC50 & Target

PAI-1[2]
体内研究
(In Vivo)

Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2]
Dosage: 5 μl of a 10% suspension of Anecortave acetate
Administration: Injected into eyes
Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels.
Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.
Clinical Trial
分子量

386.48

Formula

C23H30O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

δ-9(11)-氢化可的松醋酸酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Anecortave acetate 相关分类

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Keywords:

Anecortave7753-60-8δ-9(11)-氢化可的松醋酸酯PAI-1Plasminogen activator inhibitor-1ocularneovascularizationangiogenicneovascular diseasesInhibitorinhibitorinhibit

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