1. Signaling Pathways
  2. Immunology/Inflammation
  3. PD-1/PD-L1

PD-1/PD-L1 (程序性死亡受体1/配体1)

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. PD-1 receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on antigen-presenting cells and cancer cells, resulting in suppression of T-cell effector function and tumor immune evasion. Inhibiting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway is an attractive strategy for tumor immunotherapy.

PD-1 is expressed on activated T cells, B cells, monocytes, dendritic cells (DCs), regulatory T cells (Tregs), and natural killer T cells (NKT). It is a member of a family of immunoglobulin domain (Ig) co-receptors that modify the outcome of activation of the T cell receptor by an antigen-presenting cell (APC) or infected target cell. PD-L1 is widely and constitutively expressed on both hematopoietic and nonhematopoietic cells; e.g., naive T and B cells, vascular endothelial cells, and pancreatic islet cells, whereas PD-L2 is exclusively and inducibly expressed on professional APCs.

PD-1/PD-L1 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-19991
    BMS-1 Inhibitor 99.61%
    BMS-1 是 PD-1/PD-L1 蛋白质/蛋白质相互作用的抑制剂,IC50 为 6 到 100 nM。
  • HY-N0242
    Fraxinellone Inhibitor 99.99%
    Fraxinellone 是从芸苔科植物 Dictamnus dasycarpus 的根皮中分离出来的。 Fraxinellone 是 PD-L1 抑制剂,可抑制 HIF-1α 蛋白质合成,而不会影响 HIF-1α 蛋白质降解。 Fraxinellone 通过靶向 PD-L1,有用于癌症免疫的潜能。
  • HY-120635
    BMS-1001 hydrochloride Inhibitor 98.46%
    BMS-1001 hydrochloride 是具有口服活性的、人 PD-L1/PD-1 免疫检查点的抑制剂。BMS-1001 hydrochloride 具有细胞毒性低的特点。
  • HY-P1812A
    AUNP-12 TFA Antagonist
    AUNP-12 (NP-12) TFA 是 PD-1 信号通路的一种多肽拮抗剂,在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。AUNP-12 TFA 具有免疫激活作用、良好的抗肿瘤活性,具有更好的研究免疫相关不良事件 (irAEs) 的潜力。
  • HY-B1387
    Sulfamethoxypyridazine Inhibitor 99.67%
    Sulfamethoxypyridazine 是一种长效磺胺类药物, 用于研究疱疹性皮炎。
  • HY-P3139
    TPP-1 Inhibitor
    TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中,TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。
  • HY-P3139A
    TPP-1 TFA Inhibitor
    TPP-1 TFA 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 TFA 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中,TPP-1 TFA 通过再激活 T 细胞功能抑制肿瘤生长。
  • HY-P2477
    Human PD-L1 inhibitor IV Inhibitor
    Human PD-L1 inhibitor IV 是一种竞争性的 human PD-1 protein 抑制剂,Kd 值为 1.38 μM,可抑制人 PD-1/PD-L1 的结合。
  • HY-P2470
    Human PD-L1 inhibitor II Inhibitor
    Human PD-L1 inhibitor II 是有效 PD-L1 抑制剂,具有抗癌活性。
  • HY-P2478
    Human PD-L1 inhibitor V Inhibitor
    Human PD-L1 inhibitor V 是一种竞争性的 human PD-1 protein 抑制剂,Kd 值为 3.32 μM,可抑制人 PD-1/PD-L1 的结合。
  • HY-P2564
    Human PD-L1 inhibitor III Inhibitor
    Human PD-L1 inhibitor III 是人的 PD-L1 的抑制剂。
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