2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Avelumab

Avelumab  (Synonyms: 阿维鲁单抗; Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C)

目录号: HY-108730 纯度: ≥95.0%
COA 技术支持

Avelumab (Anti-Human PD-L1) 是一种全人源 IgG1 抗 PD-L1 单克隆抗体 (mAb)，具有潜在的抗体依赖性细胞介导细胞毒作用 (ADCC)。Avelumab 可增强多种表达 PD-L1 的癌细胞系的 ADCC。Avelumab 可用于脊索瘤的研究。

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CAS No. : 1537032-82-8

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规格 价格 是否有货 数量
1 mg ￥1950
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5 mg ￥5800
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10 mg ￥9580
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Customer Review

Other Forms of Avelumab:

Avelumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma[1].

同型

Human IgG1 lambda
推荐同型对照抗体
反应种属

Human
IC50 & Target

B7-H1/PD-L1/CD274
体外研究
(In Vitro)

Avelumab 是一种完全人源 IgG1 抗 PD-L1 单克隆抗体，具有潜在的抗体依赖性细胞介导的细胞毒作用。与同种型对照相比，Avelumab 使 JHC7 细胞中的 NK 细胞裂解增加 3.1 倍。当用 IFN-γ 处理细胞时，与同种型对照相比，Avelumab 显著增强了以下细胞系中的 NK 细胞裂解：JHC7 (7.56 倍)、UM-Chor1 (7.34 倍)、U-CH2 (2.6 倍)、MUG-Chor1 (8.38 倍)。 Avelumab 可有效提高非癌症干细胞 (CSC) 和 CSC 亚群的抗体依赖性细胞介导细胞毒性 (ADCC)，且提高程度相同[1]。
结果还表明，与 CEFT 刺激的外周血单核细胞 (PBMC) 中的同种型对照相比，添加 Avelumab 可使抗原特异性多功能 CD8+ T 细胞的频率增加五倍以上[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Avelumab 相关抗体:
体内研究
(In Vivo)

对单个肿瘤的测量表明，在 Avelumab 给药的小鼠中，肿瘤生长减缓。到肿瘤植入后第 36 天，Avelumab 给药的小鼠的平均肿瘤体积显著减小。Avelumab 给药的小鼠的 MB49 肿瘤生长减少是持久的，并导致存活率显著提高。Avelumab 给药的 10 只患有膀胱肿瘤的小鼠，结果显示 8 只小鼠的肿瘤完全消退，这已通过组织病理学证实。然而，在 CD4 或 CD8 细胞耗尽的小鼠中，Avelumab 在控制膀胱肿瘤负荷方面效果要差得多，在 CD4 T 细胞耗尽的小鼠中，肿瘤突破发生的频率更高[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

29126  [NCBI]

Accession
分子量

150 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿维鲁单抗； 阿维单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
纯度 & 产品资料

纯度: 99.30%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献
Cell Assay
[1]

To examine the relationship between a cancer stem cell (CSC) subpopulation and antibody-dependent cell-mediated cytotoxicity (ADCC) activity, UM-Chor1 cells are left untreated or treated with 50 ng/mL of IFN-γ for 24 h. Cells are then plated as targets at 50,000 cells/well in 6-well round-bottom culture plates and incubated with 2 μg/mL of Avelumab at room temperature for 30 min. NK cells are added at 2500,000 cells/well at an effector-to-target (E:T) ratio of 50:1. After 4 h, tumor cells are harvested and stained with antibodies for flow cytometry[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[3]

Female C57BL/6 mice are used in this study. Subcutaneous tumor injections are carried out by inoculating C57BL/6 mice with 1×105 MB49 parental cells on the right shaved flank. Tumor growth is measured with calipers and 8 days post-inoculation mice are assigned to treatment groups. Tumor-bearing mice are treated with Avelumab (400 µg per 100 µL) and injected i.p. three times, 3 days apart. Since Avelumab is a human IgG1, three injections have to be compressed within a 7 to 9 day window (i.e., days 9, 12, and 15 post-tumor inoculation) to avoid the onset of neutralizing mouse anti-human Ig[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Avelumab 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avelumab1537032-82-8Anti-Human PD-L1, Human Antibody MSB 0010718C MSB0010718C阿维鲁单抗 阿维单抗PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1 monoclonal antibodyInhibitorinhibitorinhibit

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