Rosnilimab  (Synonyms: 罗斯尼利单抗; ANB030)

Rosnilimab (ANB030) is a PD-1 agonist IgG1 monoclonal antibody. Rosnilimab can inhibit T cell proliferation, the secretion of inflammatory cytokines, and reduce CD4 and CD8 T cells with high PD-1 expression. Rosnilimab can be used in the research of inflammatory diseases such as colitis and rheumatoid arthritis^[1][2].

Human IgG2 kappa

Human IgG2 kappa, Isotype Control

Human

PDCD1/PD-1/CD279

Rosnilimab 在小鼠结肠炎模型中具有改善作用，可减轻小鼠体重下降、结肠炎症和 CD4 T 细胞浸润^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5133  [NCBI]

Q15116

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

146.34 kDa

2412764-40-8

液体

Colorless to light yellow

罗斯尼利单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG1 kappa

• 
  Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Rosnilimab. The EC₅₀ for this effect is 4.69 ng/mL.
• 
  Loaded Rosnilimab on AHC2 biosensor, can bind PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) with an affinity constant of 2.896E-09 M as determined in BLI assay.

• [1]. Luu K, et al. Rosnilimab, a Novel PD-1 Agonist Monoclonal Antibody, Inhibits Peripheral T Cell Proliferation and Cytokine Secretion and Reduces Circulating PD-1 High Expressing CD4 and CD8 T Cells: Results from a Phase 1 Healthy Volunteer Clinical Trial[C]//ARTHRITIS & RHEUMATOLOGY. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY, 2023, 75: 883-884.

  [2]. Linggi B, et al. P0101 Phenoty of human UC colonic tissue reveals inflammatory pathway gene expression in PD-1+ conventional and regulatory T cells which overlap with those regulated by rosnilimab in a mouse model of colitis. Journal of Crohn's and Colitis, 2025, 19(Supplement_1): i473-i473.