1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Proton Pump

Proton Pump

Proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates a protonconcentration gradient across the inner mitochondrial membrane, because there are more protons outside the matrix than inside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potential difference that works similar to that of a battery or energy storing unit for the cell. The process could also be seen as analogous to cycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, but forms a gradient that stores energy for later use.

Proton Pump 相关产品 (39):

Cat. No. Product Name Effect Purity
  • HY-100558
    Bafilomycin A1 Inhibitor 99.43%
    Bafilomycin A1,一种从链霉菌属物种中分离的大环内酯类抗生素,是特异的 vacuolar-type H+ ATPase (V-ATPase) 抑制剂。Bafilomycin A1 抑制自噬 (autophagy) 且诱导凋亡 (apoptosis)。
  • HY-128892
    EN6 Activator 99.58%
    EN6 是一种小分子体内自噬 (autophagy) 激活剂,其共价靶向溶酶体v-ATP 酶的 ATP6V1A 亚基中的半胱氨酸 277。EN6 介导的 ATP6V1A 修饰使 v-ATP 酶与 Rag 解偶联,导致 mTORC1 信号传导的抑制,溶酶体酸化增加和自噬激活。EN6 以溶酶体依赖性方式清除 TDP-43 聚集物,这是额颞叶痴呆的致病因子。
  • HY-B0572
    Zinc Pyrithione Inhibitor >98.0%
    Zinc Pyrithione能抗真菌和细菌,可通过阻断质子泵扰乱膜运输。
  • HY-17507A
    Pantoprazole sodium Inhibitor 99.89%
    Pantoprazole sodium (BY1023 sodium; SKF96022 sodium) 是质子泵抑制剂。
  • HY-B0113
    Omeprazole Inhibitor
    Omeprazole (H 16868) 是一种质子泵 (proton pump) 抑制剂 (PPI),可用于治疗胃肠道疾病。Omeprazole 竞争性抑制 CYP2C19 活性,Ki 为 2 到 6 μM。Omeprazole 还抑制革兰氏阳性菌和革兰氏阴性菌生长。
  • HY-109079
    Abeprazan Inhibitor
    Abeprazan (DWP14012) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H +,K+- ATPase,而无需酸激活。Abeprazan 是一种潜在的质子泵抑制剂,用于治疗与酸相关的疾病。
  • HY-109079A
    Abeprazan hydrochloride Inhibitor
    Abeprazan hydrochloride (DWP14012 hydrochloride) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂,用于治疗与酸相关的疾病。
  • HY-W003467
    Rabeprazole Sulfide Inhibitor
    Rabeprazole Sulfide 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种 质子泵 (proton pump) 抑制剂,可通过与胃壁细胞中的 (H+/K+)-ATPase 相互作用来抑制胃酸分泌。Rabeprazole 显着抑制幽门螺旋杆菌的活性。Rabeprazole 可用于各种消化系统疾病的研究。
  • HY-100007
    Vonoprazan Inhibitor 99.33%
    Vonoprazan (TAK-438 free base) 是有一种口服活性的 钾竞争性酸阻断剂,抑制 H+, K+-ATPase的 IC50 值为 19 nM。
  • HY-B0656A
    Rabeprazole sodium Inhibitor 99.17%
    Rabeprazole (LY307640)钠盐是质子泵抑制剂,可抗溃疡。
  • HY-101664
    Ilaprazole Inhibitor >98.0%
    Ilaprazole (IY-81149)是质子泵抑制剂;抑制H+/K+-ATPase的IC50值为6.0 μM。
  • HY-13662
    Lansoprazole Inhibitor >98.0%
    Lansoprazole(AG-1749)是质子泵抑制剂,能抑制胃酸生成。
  • HY-13662B
    (R)-Lansoprazole Inhibitor
    (R)-Lansoprazole是质子泵抑制剂,能抑制胃酸生成。
  • HY-15295
    Vonoprazan Fumarate Inhibitor 99.97%
    Vonoprazan Fumarate (TAK-438) 是有一种口服活性的 钾竞争性酸阻断剂,抑制 H+, K+-ATPase的 IC50 值为 19 nM。
  • HY-N1724
    Concanamycin A Inhibitor >98.0%
    Concanamycin A (Antibiotic X 4357B) 是一种大环内酯类抗生素,也是特异的空泡状 H+- ATP 酶 (V-ATPase) 抑制剂。
  • HY-100414
    Soraprazan Inhibitor 99.02%
    Soraprazan 是一种可逆的,见效快的肠胃 H+/K+ ATPase 抑制剂。
  • HY-B1446
    Esomeprazole magnesium Inhibitor 98.49%
    Esomeprazole magnesium 是一种 H+, K+-ATPase 抑制剂,能够有效用于上肠道疾病的研究。
  • HY-17022
    Esomeprazole Magnesium trihydrate Inhibitor
    Esomeprazole镁盐三水合物是质子泵抑制剂,能通过抑制胃壁细胞中的H+/K+ ATPase来降低酸分泌。
  • HY-100412
    Linaprazan Inhibitor 98.89%
    Linaprazan (AZD0865) 能够通过K+竞争约束抑制胃里H+,K+ -ATPase. (IC 50: 1.0 ± 0.2 μM),它对酸有很强的抑制作用。
  • HY-N2033
    Chebulinic acid Inhibitor 98.42%
    Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂,也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。
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