2. Membrane Transporter/Ion Channel Anti-infection
  3. Proton Pump Bacterial
  4. Esomeprazole

Esomeprazole  (Synonyms: (S)-Omeprazole; (-)-Omeprazole)

目录号: HY-17021 纯度: 99.07%
COA 产品使用指南

摩尔计算器

Esomeprazole ((S)-Omeprazole) 是一种有效的具有口服活性质子泵抑制剂，可通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，并可用于胃食管反流疾病的研究。

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Esomeprazole Chemical Structure

Esomeprazole Chemical Structure

CAS No. : 119141-88-7

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥231
In-stock
25 mg ￥210
In-stock
50 mg ￥350
In-stock
100 mg ￥490
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Esomeprazole 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

IC50 & Target

H+, K+-ATPase[1][2]
体外研究
(In Vitro)

Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Esomeprazole 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-468 cells
Concentration: 25 µM, 50 µM, 75 µM, 100 µM
Incubation Time: 20 hours
Result: Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.
体内研究
(In Vivo)

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury[2]
Dosage: 30 mg/kg, 300 mg/kg
Administration: Oral gavage; daily; for 19 or 11 days
Result: Significantly inhibited the progression of fibrosis throughout the lungs of the animals.
Clinical Trial
分子量

345.42

Formula

C17H19N3O3S
CAS 号
性状

固体

中文名称

埃索美拉唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (361.88 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8950 mL 14.4751 mL 28.9503 mL
5 mM 0.5790 mL 2.8950 mL 5.7901 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.07%

COA (169 KB) HNMR (239 KB) LCMS (90 KB)

产品使用指南 (1538 KB)
参考文献

Esomeprazole 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8950 mL 14.4751 mL 28.9503 mL 72.3757 mL
5 mM 0.5790 mL 2.8950 mL 5.7901 mL 14.4751 mL
10 mM 0.2895 mL 1.4475 mL 2.8950 mL 7.2376 mL
15 mM 0.1930 mL 0.9650 mL 1.9300 mL 4.8250 mL
20 mM 0.1448 mL 0.7238 mL 1.4475 mL 3.6188 mL
25 mM 0.1158 mL 0.5790 mL 1.1580 mL 2.8950 mL
30 mM 0.0965 mL 0.4825 mL 0.9650 mL 2.4125 mL
40 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8094 mL
50 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4475 mL
60 mM 0.0483 mL 0.2413 mL 0.4825 mL 1.2063 mL
80 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9047 mL
100 mM 0.0290 mL 0.1448 mL 0.2895 mL 0.7238 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Esomeprazole119141-88-7(S)-Omeprazole (-)-Omeprazole埃索美拉唑Proton PumpBacterialCYP3A4H+K+-ATPaseantacidanti-inflammationfibrosisgastroesophagealInhibitorinhibitorinhibit

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