2. Membrane Transporter/Ion Channel Anti-infection
  3. Proton Pump Bacterial Antibiotic
  4. Concanamycin A

Concanamycin A  (Synonyms: 刀豆素A; Antibiotic X 4357B; Folimycin; X 4357B)

目录号: HY-N1724 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Concanamycin A (Folimycin; Antibiotic X 4357B) 是一种大环内酯类抗生素，是空泡状 H+-ATP 酶 (V-ATPase) 抑制剂。Concanamycin A 是一种溶酶体酸化抑制剂，可用于 T 细胞介导的炎症研究。

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Concanamycin A Chemical Structure

Concanamycin A Chemical Structure

CAS No. : 80890-47-7

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规格 价格 是否有货 数量
25 μg ￥2300
In-stock
50 μg ￥3650
In-stock

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Concanamycin A 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].

IC50 & Target

Macrolide

 

体外研究
(In Vitro)

Concanamycin A can come from S. diastatochromogenes, as a microbial metabolite with immunomodulatory activity[1].
? Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while CD8+ population in mice immunized is more sensitive[2].
? Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production[3].
? Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM)[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Concanamycin A 相关抗体:

Cell Viability Assay[2]

Cell Line: CD8+ cytotoxic T lymphocytes (CTLs)
Concentration: 100 nM
Incubation Time: 0, 4, 8, 12, 16, 20 hours
Result: Induced rapid cell death instead of apoptosis at 20 h, without observed condensed nuclei.
体内研究
(In Vivo)

Concanamycin A (15 mg/kg; i.v.; 0, 10 or 24 h prior to sacrifice) induces T cell-mediated hepatitis in mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type mice[5]
Dosage: 15 mg/kg
Administration: Intravenous injection 0, 10 or 24 h prior to sacrifice
Result: Resulted significant liver injury as demonstrated by serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 h and 24 h following administration.
分子量

866.09

Formula

C46H75NO14
CAS 号
性状

固体

颜色

White to off-white

中文名称

刀豆素A
结构分类
初始来源

Streptomyces diastatochromogenes S-45
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Methanol 中的溶解度 : 10 mg/mL (11.55 mM; 超声加热助溶)

DMSO 中的溶解度 : ≥ 10 mg/mL (11.55 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1546 mL 5.7731 mL 11.5461 mL
5 mM 0.2309 mL 1.1546 mL 2.3092 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (193 KB) RP-HPLC (891 KB)

产品使用指南 (1538 KB)
参考文献

Concanamycin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Methanol / DMSO 1 mM 1.1546 mL 5.7731 mL 11.5461 mL 28.8654 mL
5 mM 0.2309 mL 1.1546 mL 2.3092 mL 5.7731 mL
10 mM 0.1155 mL 0.5773 mL 1.1546 mL 2.8865 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Concanamycin A80890-47-7Antibiotic X 4357B Folimycin X 4357B刀豆素AProton PumpBacterialAntibioticmacrolide antibioticvacuolar type H+-ATPaseV-ATPaseendocytic traffic chemical inhibitorCTLcytotoxic T lymphocytescondensed nucleiLPSNitric oxideTLR4Inhibitorinhibitorinhibit

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