1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. SGLT

SGLT (钠-葡萄糖协同转运蛋白)

SGLTs (Sodium-dependent glucose cotransporters) are a family of glucose transporters and contribute to glucose reabsorption. The two most well-known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family. The two transporters are of primary importance for glucose homeostasis by absorbing glucose from the diet in the small intestine (via SGLT1) and by reabsorbing the filtered glucose in the tubular system of the kidney (primarily SGLT2; to smaller extent via SGLT1); the latter process returns glucose into the blood stream and prevents urinary glucose loss. SGLT1 and SGLT2 have been proposed as a novel therapeutic strategy for diabetes and cardiomyopathy.

SGLT 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-15409
    Empagliflozin Inhibitor 99.93%
    Empagliflozin是一种选择性钠葡萄糖协同转运蛋白-2 (SGLT-2) 抑制剂,抑制人SGLT-2的IC50 为3.1 nM。
  • HY-N0143
    Phlorizin Inhibitor 98.79%
    Phlorizin 是一种非选择性的 SGLT 抑制剂,对于 hSGLT1hSGLT2Ki 值分别为 300 和 39 nM。Phlorizin 也是一个 Na+/K+-ATPase 抑制剂。
  • HY-N0142
    Phloretin Inhibitor 99.78%
    Phloretin (NSC 407292; RJC 02792) 是一种从夏枯草中提取的黄酮类化合物,具有抗炎活性。Phloridzin 是一种特异性、竞争性和口服活性的钠/葡萄糖协同转运蛋白 (sodium/glucose cotransporters) 抑制剂,在肠道 (SGLT1) 和肾脏 (SGLT2)。Phloretin 抑制 Yeast-made GLUT1 以及人类红细胞 GLUT1 的 IC50 值分别为 49 μM 和 61 μM。Phloretin 具有潜力用于类风湿性关节炎 (RA) 和过敏性气道炎症的相关研究。
  • HY-N4100
    Trilobatin Inhibitor 98.85%
    Trilobatin 是一种甜味剂,源自 Lithocarpus polystachyus Rehd,Trilobatin 是一种 HIV-1 抑制剂,靶向 Gp41 包膜蛋白。具有神经保护作用。Trilobatin 还是 SGLT1/2 抑制剂,可选择性诱导人肝母细胞瘤细胞增殖。
  • HY-17638
    Mizagliflozin Inhibitor 99.64%
    Mizagliflozin (DSP-3235 free base) 是一种高效、口服、选择性的 SGLT1 抑制剂,对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 的对 SGLT1 选择性是 SGLT2 的 303 倍。Mizagliflozin 是一种抗糖尿病药物,可以改善餐后血糖波动。Mizagliflozin 在改善慢性便秘方面具有潜在的作用。
  • HY-117010
    Kushenol K Inhibitor
    Kushenol K,一种从 Sophora flavescens 中提取的黄酮类抗氧化剂。Kushenol K 是 CYP3A4 的抑制剂,Ki 值为 1.35 μM。Kushenol K 对 HSV-2 具有较弱的抗病毒活性 (EC50 为 147 μM)。Kushenol K 还抑制 SGLT1SGLT2 的活性。
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