1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKCδ Inhibitors

PKCδ Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

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Sorry. There is currently no product that acts on isoform PKCδ together.

Please try each isoform separately.

PKCδ Specific Inhibitors, Activators & Modulators
Product Name PKCδ PKCα PKCβ PKCγ PKCε PKCη PKCζ PKCθ PKCμ PKCδ Selectivity Purity
Delcasertib
δPKC
                Selective Inhibitor 95.38%
PKC-theta inhibitor 1
PKCδ, Ki: 392 μM
PKCα, Ki: 1020 μM
         
PKCθ, Ki: 6 nM
  Selective Inhibitor
BJE6-106
PKCδ, IC50: 0.05 μM
PKCα, IC50: 50 μM
              Selective Inhibitor
Midostaurin
nPKC-δ, IC50: 33 nM
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
    Pan Inhibitor 99.89%
Go 6983
PKCδ, IC50: 10 nM
PKCα, IC50: 7 nM
PKCβ, IC50: 7 nM
PKCγ, IC50: 6 nM
   
PKCζ, IC50: 60 nM
 
PKCμ, IC50: 20000 nM
Pan Inhibitor 98.01%
Sotrastaurin
PKCδ, Ki: 2.1 nM
PKCα, Ki: 0.95 nM
PKCβI, Ki: 0.64 nM
 
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
  Pan Inhibitor 99.83%
Rottlerin
PKCδ, IC50: 3 μM (Porcine spleen)
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
    Pan Inhibitor >95.0%
Ruboxistaurin hydrochloride
PKCδ, IC50: 250 nM
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
      Pan Inhibitor 99.84%
Ingenol Mebutate
PKC-δ, Ki: 0.376 nM
PKC-α, Ki: 0.3 nM
PKC-β, Ki: 0.105 nM
PKC-γ, Ki: 0.162 nM
PKC-ε, Ki: 0.171 nM
        Pan Modulator 98.44%
(-)-Indolactam V
PKCδ-C1B, Kd: 8.3 nM
PKCδ-C1A, Kd: 1900 nM
PKCα-C1A-long, Kd: 20.8 nM
PKCα-C1B-long, Kd: 4000 nM
PKCβ-C1A-long, Kd: 18.9 nM
PKCβ-C1B, Kd: 137 nM
PKCγ-C1A, Kd: 138 nM
PKCγ-C1B, Kd: 213 nM
PKCγ-CRD2, Ki: 1030 nM
PKCε-C1B, Kd: 7.7 nM
PKCε-C1A, Kd: 4110 nM
PKCη-CRD2, Ki: 3.36 nM
PKCη-C1B, Kd: 5.5 nM
PKCη-C1A, Kd: 3770 nM
 
PKCθ-C1B, Kd: 8.7 nM
  Pan Activator 99.18%
AS2521780
PKCδ, IC50: 160 nM
PKCα, IC50: 160 nM
   
PKCε, IC50: 18 nM
   
PKCθ, IC50: 0.48 nM
  Pan Inhibitor