1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor

TAM Receptor (TAM受体)

TAM receptors, comprising of Tyro3, Axl and Mertk receptors, are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells. The TAM family of receptors and their ligands Gas6 and Protein S (PROS1) are required for the optimal phagocytosis of apoptotic cells in the mature immune, nervous, and reproductive systems.

TAMs are three homologous type I receptor-tyrosine kinases that are activated by endogenous ligands, PROS1 and GAS6. These ligands can either activate TAMs as soluble factors, or, in turn, opsonize phosphatidylserine (PS) on apoptotic cells (ACs) and serve as bridging molecules between ACs and TAMs. Abnormal expression and activation of TAMs have been implicated in promoting proliferation and survival of cancer cells, as well as in suppressing anti-tumor immunity.

TAM Receptor 相关产品 (4):

目录号 产品名 作用方式 纯度
  • HY-114166
    2-D08 Inhibitor 98.44%
    2-D08是一种有细胞透性的小泛素样修饰蛋白 (sumoylation) 抑制剂。2-D08也可抑制 AxlIC50 为 0.49 nM。
  • HY-12964
    SGI-7079 Inhibitor 99.65%
    SGI-7079 是一种 ATP-竞争性 Axl 抑制剂, 显著抑制 SUM149 和 KPL-4 细胞增殖,IC50 分别为 0.43 和 0.16 μM。
  • HY-126216
    TAM-IN-2 Inhibitor 99.89%
    TAM-IN-2 是专利 US 20170275290 A1 中提到的 TAM 抑制剂,吡咯并三嗪化合物 0904。
  • HY-124066
    RU-302 Inhibitor
    RU-302 是一种非选择性的TAM 抑制剂,阻断 TAM Ig1 胞外域和 Gas6 Lg 结构域之间的界面。RU-302 用低微摩尔 IC50 有效阻断 Gas6 诱导的 Axl 受体活化,并有效抑制肺癌肿瘤的生长。
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