1. Cell Cycle/DNA Damage
    Apoptosis
  2. Telomerase
    Apoptosis
  3. RHPS4

RHPS4 

目录号: HY-101089 纯度: 98.62%
产品使用指南

RHPS4 是有效的端粒酶 (telomerase) 抑制剂 (IC50 = 0.33 μM)。RHPS4 是 DNA 损伤的诱导剂。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

RHPS4 Chemical Structure

RHPS4 Chemical Structure

CAS No. : 390362-78-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
5 mg ¥750
In-stock
10 mg ¥1200
In-stock
25 mg ¥2400
In-stock
50 mg ¥4000
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer[1][2].

IC50 & Target

IC50: 0.33 μM (telomerase in the TRAP assay)[1].

体外研究
(In Vitro)

RHPS4 could sensitize tumor cells to anticancer agents that act via disparate mechanisms[1].
RHPS4 (0.5-1 μM, 15 days) induces a senescent-like growth arrest in MCF-7 cells[1].
RHPS4 (1 μM, 4 days) induces phosphorylation of H2AX in transformed and tumor cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7, MCF-7 vector control, and MCF-7 c81 cells.
Concentration: 0, 0.2, 0.5, or 1 μM.
Incubation Time: 7 days.
Result: Inhibited cell proliferation.
体内研究
(In Vivo)

RHPS4 (15 mg/kg, iv, 15 days) treatment produces a marked inhibition of tumor weight (tumor weight inhibition [TWI] about 80%; P < 0.001) in a very short time, and this effect persists for at least 30 days. A complete tumor response is observed in 80% of mice, and 40% are cured[2].
In all the other tumor xenografts, RHPS4 treatment produces about 50% (P < 0.001) TWI at the nadir of the effect and, more important, results in a delay of tumor growth of about 15 (M14 and PC3) and 10 (HT29 and H460) days[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models)[2].
Dosage: 15 mg/kg.
Administration: IV, daily for 15 consecutive days.
Result: Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.
分子量

458.48

Formula

C23H20F2N2O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 1 mg/mL (2.18 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1811 mL 10.9056 mL 21.8112 mL
5 mM --- --- ---
10 mM --- --- ---
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
RHPS4
目录号:
HY-101089
需求量: