2. Cell Cycle/DNA Damage
  3. G-quadruplex Telomerase DNA/RNA Synthesis
  4. BMVC

BMVC 是一种有效的 G-四联体 (G4) 稳定剂和选择性的端粒酶 (telomerase) 抑制剂，IC50 约为 0.2 μM。BMVC 抑制 Taq DNA 聚合酶，IC50 约为 2.5 μ M。BMVC 提高了端粒 G4 结构的熔化温度，并加速了端粒长度的缩短。抗癌活性。

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BMVC Chemical Structure

BMVC Chemical Structure

CAS No. : 627810-06-4

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规格 价格 是否有货 数量
1 mg ￥1363
In-stock
5 mg ￥3000
In-stock
10 mg ￥4800
In-stock
25 mg ￥9500
In-stock
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100 mg   询价  

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Customer Review

BMVC 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities[1][2].

IC50 & Target

IC50: ~0.2 μM (Telomerase)[1]
G-quadruplex[1]
IC50: ~2.5 μM (Taq DNA polymerase)[1]
体外研究
(In Vitro)

BMVC (0.5 μM; 0-18 days; H1299 cells) treatment markedly increases the percentage of sub-G1-phase cells after 18 days[1].
BMVC (0.5 μM; 0-18 days; H1299 cells) long-term treatment leads to ceasing of cell growth and eventually cell death through apoptosis. The long-term BMVC treatment induces senescence program in H1299 cells[1].
In BMVC-treated cancer cells, hallmarks of senescence, including morphologic changes, detection of senescence-associated β-galactosidase activity, and decreasesd bromodeoxyuridine incorporation, are detected. The BMVC-induced senescence phenotype is accompanied by progressive telomere shortening and detection of the DNA damage foci, indicating that BMVC caused telomere uncapping after long-term treatments[1].
BMVC also suppresses the tumor-related properties of cancer cells, including cell migration, colony-forming ability, and anchorage-independent growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMVC 相关抗体:

Cell Cycle Analysis[1]

Cell Line: H1299 cells
Concentration: 0.5 μM
Incubation Time: 0 day, 6 days, 12 days, 18 days
Result: The percentage of sub-G1-phase cells was markedly increased after 18 days.

Apoptosis Analysis[1]

Cell Line: H1299 cells
Concentration: 0.5 μM
Incubation Time: 0 day, 6 days, 12 days, 18 days
Result: Increased apoptotic cells.
体内研究
(In Vivo)

BMVC (1 mg/kg; intraperitoneal injection; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) treatment delays tumorigenic potential of cancer cells in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cAnN.Cg-Foxn1nu/CrlNarl mice injected with H1299 cells[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; every 3 day
Result: The growth rates of tumors in animals were significantly slower than that of control animals. The tumor cells of the mice were indeed entering apoptosis.
分子量

657.33

Formula

C28H25I2N3
CAS 号
性状

固体

颜色

Orange to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (15.21 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5213 mL 7.6065 mL 15.2131 mL
5 mM 0.3043 mL 1.5213 mL 3.0426 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

BMVC 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5213 mL 7.6065 mL 15.2131 mL 38.0326 mL
5 mM 0.3043 mL 1.5213 mL 3.0426 mL 7.6065 mL
10 mM 0.1521 mL 0.7607 mL 1.5213 mL 3.8033 mL
15 mM 0.1014 mL 0.5071 mL 1.0142 mL 2.5355 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMVC627810-06-4G-quadruplexTelomeraseDNA/RNA SynthesisAnticancercarbazoleapoptosissenescenceβ-galactosidaseDNAdamagetelomeremigrationcolony-formingInhibitorinhibitorinhibit

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