1. Protein Tyrosine Kinase/RTK
  2. c-Fms
  3. PLX5622

PLX5622 

目录号: HY-114153
产品使用指南

PLX5622 是高度选择性的、能透过血脑屏障的、口服有效的 CSF1R 抑制剂,可用于病程发展前和过程中,扩大的和特异性的小胶质细胞的消除。PLX5622 具有较好的药理学特性。

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PLX5622 Chemical Structure

PLX5622 Chemical Structure

CAS No. : 1303420-67-8

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Description

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor, for extended and specific microglial elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals[1].

IC50 & Target

CSF1R[1].

Molecular Weight

395.41

Formula

C₂₁H₁₉F₂N₅O

CAS No.

1303420-67-8

SMILES

COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PLX5622
目录号:
HY-114153
需求量:

PLX5622

Cat. No.: HY-114153