2. Immunology/Inflammation
  3. CD73
  4. Oleclumab

Oleclumab  (Synonyms: MEDI9447)

目录号: HY-P99039 纯度: 99.80%
COA

摩尔计算器

Oleclumab (MEDI9447) 是一种靶向 CD73 的人源 IgG1λ 单克隆抗体，可抑制胞外酶 CD73 核酸外切酶活性。Oleclumab 可调整肿瘤微环境中骨髓和淋巴浸润白细胞群组成，具有抗肿瘤活性。

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Oleclumab Chemical Structure

Oleclumab Chemical Structure

CAS No. : 1803176-05-7

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规格 价格 是否有货 数量
1 mg ￥4500
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Oleclumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity[1][2].

体内研究
(In Vivo)

Oleclumab (10 mg/kg; ip; 每 3 天一次，共 4 次) 在小鼠 Balb/c 同基因 CT26 结肠癌肿瘤模型中，增加活化 CD8S+ 淋巴细胞群的比例，并显著抑制肿瘤生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine, Balb/c, syngeneic CT26 colon carcinoma tumor model[2]
Dosage: 10 mg/kg
Administration: ip; 2 time per week, for 2 weeks
Result: Inhibited tumor growth by 50% or greater from study day 7 to study day 16 when compared with isotype control antibody-treated groups.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

奥来鲁单抗；奥来珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.80%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Oleclumab 相关分类

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Keywords:

Oleclumab1803176-05-7MEDI9447奥来鲁单抗奥来珠单抗MEDI 9447MEDI-9447CD73ecto-5′-nucleotidase, NT5Ehuman IgG1λ anti-CD73 monoclonal antibodyanti-tumor activityInhibitorinhibitorinhibit

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