2. Immunology/Inflammation
  3. CD73
  4. Uliledlimab

Uliledlimab  (Synonyms: 尤莱利单抗; TJ004309)

目录号: HY-P99169 纯度: 99.35%
COA 技术支持

Uliledlimab 是一种有效的抗 CD73 人源化单克隆抗体。Uliledlimab 抑制胞外单磷酸腺苷 (AMP) 向腺苷的转化。Uliledlimab 可用于癌症的研究。

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CAS No. : 2378407-27-1

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规格 价格 是否有货 数量
1 mg ￥3100
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Uliledlimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Uliledlimab is a potent against CD73 humanizedized monoclonal antibody. Uliledlimab inhibits the conversion of extracellular adenosine monophosphate (AMP) to adenosine. Uliledlimab can be used in research of cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

NT5E/CD73
体外研究
(In Vitro)

Uliledlimab 通过 C 末端结构域结合模式与 CD73 蛋白结合，从而完全抑制 CD73 的酶活性。Uliledlimab 通过阻断腺苷的产生，解除免疫细胞的抑制，增强 CD8+T 细胞和巨噬细胞的活性，从而增强抗肿瘤免疫反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Uliledlimab 相关抗体:
体内研究
(In Vivo)

Uliledlimab 单独使用或与 PD-L1 抑制剂 Atezolizumab (HY-P9904) 联合使用时，可抑制实体肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
基因 ID

4907  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.04 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

尤莱利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized CD73/5'-Nucleotidase Protein, Human can bind Uliledlimab. The EC50 for this effect is 2.1 ng/mL.
纯度 & 产品资料

纯度: 99.35%

COA (265 KB) SDS-PAGE (75 KB) SEC-HPLC (105 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Uliledlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uliledlimab2378407-27-1TJ004309尤莱利单抗TJ 004309TJ-004309CD73ecto-5′-nucleotidase, NT5Ehumanized monoclonal antibodyanticanceradenosine monophosphateadenosineInhibitorinhibitorinhibit

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目录号：
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