1. Signaling Pathways
  2. Immunology/Inflammation
  3. Glycoprotein VI

Glycoprotein VI (糖蛋白VI)

GPVI

Glycoprotein VI (GPVI) is a membrane glycoprotein unique to platelets and has been identified as a physiological receptor for collagen. Damage to a vessel wall exposes the subendothelial component collagen to platelets in the blood flow. Interaction of platelets with collagen via the receptor GPVI results in platelet activation and adhesion--the processes that are essential for thrombus formation. On the platelet surface, GPVI is present as a complex with the homodimeric Fc receptor y-chain (FcRgamma with a possible stoichiometry of two GPVI molecules and one FcRgamma dimer). When collagen binds to GPVI, a platelet activation cascade is initiated by tyrosine phosphorylation of the immunoreceptor tyrosine-based activation motif of FcRgamma and this phosphorylation induces the formation of a large complex composed from many signal-transducing proteins. In flow adhesion experiments that closely approximate physiological conditions, GPVI is essential for the formation of large platelet aggregates on collagen.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125053A
    Batifiban TFA Antagonist 99.58%
    Batifiban TFA,一种环肽,是一种血小板糖蛋白 GPⅡb/Ⅲa 拮抗剂,并抑制血小板聚集。Batifiban 阻断循环玻连蛋白与整合素 ανβ3 的结合。
    Batifiban TFA
  • HY-144390
    (S)-S007-1558 99.78%
    (S)-S007-1558 (compound 5) 是一种糖蛋白 VI (GPVI) 血小板受体拮抗剂。(S)-S007-1558 抑制胶原蛋白诱导的血小板聚集,IC50 为 25.3 μM。
    (S)-S007-1558
  • HY-115912
    GPVI antagonist 3 Antagonist
    GPVI antagonist 3 (Compound 2) 是 Glycoprotein VI (GPVI) 的潜在拮抗剂。GPVI antagonist 3 的IC50值分别为:胶原蛋白为1.01 μM,CRP为1.92 μM,convulxin为7.24 μM,凝血酶为51.74 μM。糖蛋白 VI (GPVI) 是一种血小板主要胶原受体,是有效和安全的抗血栓研究的靶点。GPVI antagonist 3 是一种很有前途的抗血小板活性分子。
    GPVI antagonist 3
  • HY-115911
    GPVI antagonist 2 Antagonist
    GPVI antagonist 2 (Compound 1) 是 Glycoprotein VI (GPVI) 的潜在拮抗剂。GPVI antagonist 2 的IC50值分别为:胶原蛋白为 0.35 μM μM,CRP为 0.80 μM,convulxin为 195.2 μM,凝血酶为81.38 μM。糖蛋白 VI (GPVI) 是一种血小板主要胶原受体,是有效和安全的抗血栓研究的靶点。GPVI antagonist 2 是一种很有前途的抗血小板活性分子。
    GPVI antagonist 2
  • HY-125615
    DMP 728 methanesulfonate Antagonist
    DMP 728 methanesulfonate 是一种血小板糖蛋白 (GP) IIb/IIIa 受体拮抗剂。DMP 728 methanesulfonate 显示出了剂量依赖性的抗血小板和抗血栓效果。DMP 728 methanesulfonate 可用于冠状动脉和外周动脉血栓栓塞性疾病中的有效抗血栓剂的研究。
    DMP 728 methanesulfonate
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