2. Immunology/Inflammation
  3. Glycoprotein VI
  4. Anti-GPC-2 Antibody (CT3)

Anti-GPC-2 Antibody (CT3) 

目录号: HY-P990842 纯度: 95%
COA 技术支持

Anti-GPC-2 Antibody (CT3) 是一种小鼠 IgG1 κ 嵌合抗体，靶向人 GPC-2。Anti-GPC-2 Antibody (CT3) 与糖蛋白-2 (GPC2) 的肿瘤相关外显子 3 和 10 发生反应。Anti-GPC-2 Antibody (CT3) 可用于癌症的研究，如神经母细胞瘤。

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Anti-GPC-2 Antibody (CT3)

Anti-GPC-2 Antibody (CT3) Chemical Structure

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1 mg ￥2000
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Anti-GPC-2 Antibody (CT3) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-GPC-2 Antibody (CT3) is a kind of mouse IgG1 κ chimeric antibody, targeting to human GPC-2. Anti-GPC-2 Antibody (CT3) reacts with tumor-associated exons 3 and 10 of glypicans-2 (GPC2). Anti-GPC-2 Antibody (CT3) can be used for the research of cancer, such as neuroblastoma[1].

同型

Mouse IgG1 kappa
反应种属

Human
IC50 & Target

GPC-2
体外研究
(In Vitro)

Anti-GPC-2 Antibody (CT3) (1 μg/mL) 可与 GPC2 的肿瘤相关外显子 3 和 10 结合[1]。
Anti-GPC-2 Antibody (CT3) (携带 CT3 单链可变片段 (scFv) 的 CAR-T 细胞) (24 h) 可杀死近 70% 的 GPC2 过表达 A431 和 IMR5 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-GPC-2 Antibody (CT3) 相关抗体:
体内研究
(In Vivo)

Anti-GPC-2 Antibody (CT3) (携带 CT3 单链可变片段 (scFv) 的 CAR-T 细胞) (10 M，静脉注射) 可使负荷 IMR5 肿瘤 NSG 小鼠的肿瘤消退并延长其生存期[1]。
Anti-GPC-2 Antibody (CT3) (携带 CT3 单链可变片段 (scFv) 的 CAR-T 细胞) (2 M，静脉注射) 可使负荷 NBEB 肿瘤 NSG 小鼠的肿瘤消退并延长其生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IMR5 tumor mice (5-week, female, NSG mice)[1]
Dosage: 10 M (CAR T cells harboring the single-chain variable fragment (scFv) of the CT3)
Administration: Intravenously injection
Result: Led to a reduction in tumor size and suppressed tumor growth.
Prolonged survival of mice.
基因 ID

71951  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-GPC-2 Antibody (CT3) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-GPC-2 Antibody (CT3)Glycoprotein VIGPVIGPC-2NeuroblastomaA431IMR5NBEBInhibitorinhibitorinhibit

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