Uridine 5′-diphosphoglucose  (Synonyms: UDP-D-Glucose)

Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue^[1][2][3][4].

Uridine 5’-diphosphoglucose (0-100 μM, 24 小时) 上调 P2Y14 受体的表达，诱导中性粒细胞凋亡^[2]。
Uridine 5’-diphosphoglucose (1 μM, 24 小时) 与 PPTN (HY-110322A) 联合使用比单独使用更抑制中性粒细胞中 CCL3、IL -1 β、IL - 12a、TNF-α 等炎症因子 mRNA 水平和上调中性粒细胞中 IL - 10、TGF-β1、YM1 等抗炎因子 mRNA 水平^[2]。
大鼠肝脏中 uridine 5’-diphosphoglucose (5 或 20 mM，孵育 3 小时) 的耗竭与分泌和组织糖蛋白的糖基化降低有关，影响大鼠肾小球基底膜 (GBM) 合成率^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

566.30

C₁₅H₂₄N₂O₁₇P₂

133-89-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.

  [2]. Li K, et al. Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury[J]. Life Sci. 2023 Aug 1;326:121805.  [Content Brief]

  [3]. Cortes P, Dumler F, Levin NW. De novo pyrimidine nucleotide biosynthesis in isolated rat glomerul[J]i. Kidney Int. 1986 Jul;30(1):27-34.  [Content Brief]

  [4]. Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.  [Content Brief]