2. Anti-infection
  3. Bacterial
  4. Amifloxacin

Amifloxacin  (Synonyms: 氨氟沙星; Win49375)

目录号: HY-U00221 纯度: 99.23%
COA 产品使用指南

摩尔计算器

Amifloxacin (Win49375) 是一种合成的喹诺酮类抗菌剂。

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Amifloxacin Chemical Structure

Amifloxacin Chemical Structure

CAS No. : 86393-37-5

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规格 价格 是否有货 数量
1 mg ￥5500
In-stock
5 mg ￥7500
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Amifloxacin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amifloxacin (Win49375) is a synthetic antibacterial agent of the quinolone class.

IC50 & Target

Antibacterial[1]
体外研究
(In Vitro)

Amifloxacin (WIN 49375) is active in vitro against Pseudomonas aeruginosa isolates and shows moderate activity against Staphylococcus aureus, with MICs of less than or equal to 2 μg/mL.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amifloxacin 相关抗体:
体内研究
(In Vivo)

Amifloxacin (WIN 49375) is highly active by the oral route, with 50% effective doses within two- to threefold of those obtained with parenteral medication. The effectiveness of Amifloxacin with various routes of medication is demonstrated with these experimental infections. When mice infected intraperitoneally with E. coli Vogel are medicated at 0.5-h postinfection subcutaneously, intravenously, or orally the ED50s for Amifloxacin are 0.6, 0.8, and 1.0 mg/kg, respectively[1]. Blood radioactivity peaks at 0.5 h after oral administration of [14C]Amifloxacin mesylate to rats at 20 mg/kg and is equivalent to 7.1±0.26 μg of Amifloxacin per mL. From 0.75 to 4 h, blood radioactivity decreases rapidly from 7.0±0.25 μg/mL to 1.2±0.12 μg/mL. Between 8 and 48 h the rate of decline in blood radioactivity slows and is more complex. At 48 h, the blood radioactivity is equivalent to 0.14±0.02 μg/mL. Blood levels of radioactivity after i.v. administration of [14C]Amifloxacin mesylate to rats at 20 mg/kg decrease from 29.1±0.85 μg/mL at 1.0 min to 14.4±0.52 μg/mL at 10 min. From 0.25 to 4 h blood radioactivity decreases from 13.0±0.42 μg/mL to 0.97±0.09 μg/mL in a log-linear manner. The rate of elimination from 4 to 24 h is slower and more complex. At 24 h, blood radioactivity is equivalent to 0.12±0.01 ug/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

334.35

Formula

C16H19FN4O3
CAS 号
性状

固体

颜色

White to light yellow

中文名称

氨氟沙星；氨氟哌酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (149.54 mM; 超声助溶; 碱性条件溶解 (NaOH 调节，pH≈11))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9909 mL 14.9544 mL 29.9088 mL
5 mM 0.5982 mL 2.9909 mL 5.9818 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Animal Administration
[2]

Rats[2]
In each study, groups of eight Sprague-Dawley rats (four per sex) are dosed either orally bygavage or intravenously via the jugular vein with [14C] Amifloxacin mesylate at 20 mg/kg. All doses are prepared as solutions in distilled water. Orally medicated animals are fasted overnight before dosing. Rats in absorption studies are held in restrainers while serial blood samples are collected from the tail vein into 50 μL heparinized capillary tubes. Rats in the excretion and distribution studies are maintained in individual metabolism cages. In the distribution study, groups of rats are killed at either 0.5 or 6.0 h, blood is collected from the abdominal aorta, and tissues and organs are dissected.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Amifloxacin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9909 mL 14.9544 mL 29.9088 mL 74.7719 mL
5 mM 0.5982 mL 2.9909 mL 5.9818 mL 14.9544 mL
10 mM 0.2991 mL 1.4954 mL 2.9909 mL 7.4772 mL
15 mM 0.1994 mL 0.9970 mL 1.9939 mL 4.9848 mL
20 mM 0.1495 mL 0.7477 mL 1.4954 mL 3.7386 mL
25 mM 0.1196 mL 0.5982 mL 1.1964 mL 2.9909 mL
30 mM 0.0997 mL 0.4985 mL 0.9970 mL 2.4924 mL
40 mM 0.0748 mL 0.3739 mL 0.7477 mL 1.8693 mL
50 mM 0.0598 mL 0.2991 mL 0.5982 mL 1.4954 mL
60 mM 0.0498 mL 0.2492 mL 0.4985 mL 1.2462 mL
80 mM 0.0374 mL 0.1869 mL 0.3739 mL 0.9346 mL
100 mM 0.0299 mL 0.1495 mL 0.2991 mL 0.7477 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amifloxacin86393-37-5Win49375氨氟沙星氨氟哌酸Win 49375Win-49375BacterialInhibitorinhibitorinhibit

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