2. Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. A-259745

A-259745 是一种具有口服活性的抗有丝分裂剂，结合到微管蛋白 (tubulin) 的秋水仙碱结合位点。A-259745 对多药耐药和非多药耐药癌细胞系均表现出强效的体外细胞毒活性，对 HCT-15 和 NCI-H460 细胞系的 ED50 值分别为 0.018 μM 和 0.028 μM。A-259745 抑制微管蛋白 (tubulin) 聚合作用，破坏有丝分裂纺锤体的动态平衡，使分裂细胞停滞在中后期，并随后诱导凋亡 (apoptosis)。A-259745 在小鼠肿瘤模型中显示出剂量依赖性的抗肿瘤疗效。A-259745 可用于癌症研究。

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A-259745

A-259745 Chemical Structure

CAS No. : 256934-83-5

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A-259745 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED50 values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer[1].

分子量

366.41

Formula

C21H22N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-259745 相关分类

  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-259745256934-83-5A-289099A259745A 259745A289099A 289099Microtubule/TubulinApoptosisAntimitoticHCT-15NCI-H460cancertubulinInhibitorinhibitorinhibit

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产品名称：
A-259745
目录号：
HY-101741
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