1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. A-935142

A-935142 是 hERG (Kv 11.1) 通道激活剂。A-935142 通过促进激活、减少失活和减缓失活以复杂方式增强 hERG 电流,并缩短心房和心室复极。

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A-935142 Chemical Structure

A-935142 Chemical Structure

CAS No. : 1031335-85-9

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1 mg ¥3995
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  • 生物活性

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生物活性

A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization[1][2].

体外研究
(In Vitro)

A-935142 shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers[1].
A-935142 shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner. A-935142 (60μM) increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation. A-935142 significantly reduces the time constants τ of hERG channel activation at two example voltages (-10 mV: tau=100+/-17 ms vs. 164+/-24 ms, n=6, P<0.01; +30 mV: tau=16.7+/-1.8 ms vs. 18.9+/-1.8 ms, n=5, P<0.05) and shifts the voltage-dependence for hERG activation in the hyperpolarizing direction by 9 mV[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

352.35

Formula

C18H19F3N2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
A-935142
目录号:
HY-113673
需求量: