a-Helical Corticotropin Releasing Factor (12-41) 

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect^[1][2].

a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.^[2].
a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3497.01

C₁₅₂H₂₅₁N₄₃O₄₇S₂

158535-55-8

FHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47.  [Content Brief]

  [2]. Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.