2. Apoptosis
  3. Apoptosis
  4. ABT-510

ABT-510 是一种抗血管生成 TSP 肽 (thrombospondin-1 类似物)，能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 还可减少小鼠炎症性肠病模型的血管生成和炎症反应。ABT-510 可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。

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Custom Peptide Synthesis

ABT-510 Chemical Structure

ABT-510 Chemical Structure

CAS No. : 251579-55-2

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ABT-510 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD)[1][2].

体外研究
(In Vitro)

ABT-510 (1，5，10，20，50 nM；24 h) 诱导 ID 8 细胞凋亡，(50 nM，24 h) 增加人类上皮性癌症细胞系 SKOV3、OVCAR3 和 CAOV3 的凋亡发生率[1]。
ABT-510 (0-10 μM; 7 天) 抑制了 NO 刺激的血管细胞向细胞外基质的生长和侵袭。ABT-510 可阻断肿瘤驱动的血管细胞生长、NO 驱动的 cGMP 通量以及 CD36 介导的脂肪酸吸收。[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABT-510 相关抗体:

Apoptosis Analysis[1]

Cell Line: ID8, SKOV3, OVCAR3, and CAOV3 cells
Concentration: 1, 5, 10, 20, 50 nM
Incubation Time: 24 h
Result: Induced ID8 cells apoptosis and increased in apoptosis in the human EOC cell lines SKOV3, OVCAR3, and CAOV3.

Apoptosis Analysis[3]

Cell Line: Tissue biopsies of B16F10 melanoma tumors grown in C57BL/6 mice
Concentration: 0-10 μM
Incubation Time: 7 days
Result: Inhibited NO-stimulated vascular cell outgrowth into and invasion through extracellular matrix.
体内研究
(In Vivo)

ABT-510 (100 mg/kg；腹腔注射；每天一次，持续90天) 在体内诱导细胞凋亡，使小鼠的卵巢上皮肿瘤大小、腹水量和继发性病变扩散显著减少[1]。
ABT-510 (60 mg/kg；皮下渗透微型泵；每天一次，持续7天) 降低炎症性肠病小鼠模型中的血管生成和炎症[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TSP-1-Null mice (C57BL/6 background; orthotopic, syngeneic model of epithelial ovarian cancer)[1].
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; single daily for 90 days
Result: Reduced ovarian tumor growth in wild-type and TSP-1-Null Mice.
Significantly reduced the volume of ascites and completely abolished the formation of peritoneal lesions.
Reversed ovarian tumor hypervascularization and increased the proportion of mature blood vessels.
Animal Model: TSP-1-Null mice (C57BL/6 background; 6-week-old; DSS-induced inflammatory bowel disease murine model)[2].
Dosage: 60 mg/kg
Administration: Subcutaneously implanted osmotic minipumps (0.5µL/h); single daily for 7 days
Result: Significantly delayed DSS-induced bleeding and improved the overall severity of disease. Significantly diminished inflammation grading and angiogenesis
Clinical Trial
分子量

994.23

Formula

C46H83N13O11
CAS 号
Sequence Shortening

Ac-{Gly-Me}-GVIT-{Nva}-IRP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABT-510 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-510251579-55-2ABT510ABT 510ApoptosisEOCepithelial ovarian cancerIBDID8SKOV3OVCAR3and CAOV3Inhibitorinhibitorinhibit

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目录号：
HY-13545
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