2. Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Cholinesterase (ChE) Reactive Oxygen Species
  4. AChE/BChE-IN-16

AChE/BChE-IN-16 (compound C7) 是一种有效的胆碱酯酶 (ChE) 抑制剂，对人乙酰胆碱酯酶 (hAChE) 和人丁酰胆碱酯酶 (hBuChE) 的 IC50 值分别为 30 nM 和 48 nM。AChE/BChE-IN-16 表现出卓越的保护 PC12 细胞免受 H2O2 诱导的细胞凋亡的能力，并有效抑制活性氧 (ROS) 的产生。

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AChE/BChE-IN-16 Chemical Structure

AChE/BChE-IN-16 Chemical Structure

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AChE/BChE-IN-16 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC50s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H2O2-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS)[1].

IC50 & Target[1]

hAChE

30 nM (IC50)

hBCHE

48 nM (IC50)

分子量

551.65

Formula

C33H34FN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BChE-IN-16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-16Cholinesterase (ChE)Reactive Oxygen SpecieshAChE/hBChE InhibitorROSAlzheimer's diseasecholinesteraseInhibitorinhibitorinhibit

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