2. Neuronal Signaling
  3. Amyloid-β
  4. Aducanumab

Aducanumab  (Synonyms: BIIB037)

目录号: HY-P9967 纯度: 99.25%
COA

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Aducanumab (BIIB037) 是一种选择性靶向聚集的 β 淀粉样蛋白 (Aβ) 的人单克隆抗体。Aducanumab 显示出脑渗透性，能够用于阿尔茨海默病 (AD) 研究。

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Aducanumab Chemical Structure

Aducanumab Chemical Structure

CAS No. : 1384260-65-4

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Aducanumab 相关抗体

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  • 生物活性

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生物活性

Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research[1].

体内研究
(In Vivo)

Aducanumab (30 mg/kg，腹腔注射，单剂量) 在 22 个月大的 Tg2576 转基因小鼠中结合所有形态类型的脑 Aβ 斑块，包括弥漫性 Aβ 沉积和致密性 Aβ 斑块[1]。
Aducanumab (0.3-30 mg/kg, 腹腔注射, 每周一次, 6 个月) 在 9.5 到 15.5 个月大的 Tg2576 转基因小鼠中以剂量依赖性方式减少可溶性和不溶性 Aβ[1]。
Aducanumab (10 mg/kg, 腹腔注射, 每周, 6 个月) 可将 18 个月大的 Tg2576 小鼠的细胞内钙恢复至控制水平[2]。
Aducanumab (0.4-1 mg/mL, 脑室注射, 20 分钟) 在 Tg2576 小鼠中可导致淀粉样蛋白负荷快速减少，从而促进斑块清除[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 9.5- to 15.5-month-old Tg2576 transgenic mice [1]
Dosage: 0.3-30 mg/kg
Administration: Intraperitoneal injection (i.p.), weekly, 6 months
Result: Increased recruitment of Iba-1-positive microglia to Aβ plaques.
Animal Model: 18-month-old Tg2576 mice[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), weekly, 6 months
Result: Restored neurite baseline calcium to control levels.
Decreased the number of neurites with elevated levels of calcium after 2 weeks.
Decreased the percentage of cell bodies with calcium overload.
Restored the levels of VILIP and SERCA to control levels.
Increased the cell numbers of NR1 and NR2A.
Animal Model: 22-month-old transgenic Tg2576 mice[2]
Dosage: 0.4-1 mg/mL
Administration: Intracerebroventricular injection (ICV), 20 min
Result: Decreased the number of amyloid plaque.
Decreased the size of the remaining individual plaques.
Reduced amyloid plaque burden.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿杜那单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.25%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Aducanumab 相关分类

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Keywords:

Aducanumab1384260-65-4BIIB037阿杜那单抗BIIB 037BIIB-037Amyloid-ββ-amyloid peptideAβAbetaamyloid betahuman monoclonal antibodyAlzheimer's diseasebrain penetrationInhibitorinhibitorinhibit

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