2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AM12

AM12 抑制镧系元素诱发的 TRPC5 活性，IC50 为 0.28 μM。

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AM12 Chemical Structure

AM12 Chemical Structure

CAS No. : 2387510-84-9

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规格 价格 是否有货 数量
5 mg ￥2565
3 - 4 周
10 mg ￥4104
3 - 4 周
50 mg   询价  
100 mg   询价  

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AM12 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM[1].

IC50 & Target

IC50: 0.28 μM (TRPC5)[1]
体外研究
(In Vitro)

AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1].
AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AM12 相关抗体:
分子量

349.13

Formula

C15H9BrO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM122387510-84-9AM 12AM-12TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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