TRP Channel Inhibitors

TRPC

TRPM

TRPV

TRPA

TRPML

TRP Channel Ligands, Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	TRPC	TRPM	TRPV	TRPA	TRPML	Purity
Rosiglitazone	TRPC5, EC₅₀: 30 μM					99.94%
Trpvicin			TRPV3			99.4%
GSK2220691			TRPV4
LY3526318				TRPA1		99.92%
GSK1016790A			TRPV4			99.93%
Anandamide			TRPV1			≥99.0%
ML-SI3					TRPML1, IC₅₀: 4.7 μM	99.91%
SB-366791			hTRPV1, IC₅₀: 5.7 nM			98.11%
CIM0216		TRPM3				99.94%
Icilin		TRPM8				99.26%
(1R,2R)-ML-SI3					TRPML1, IC₅₀: 1.6 μM TRPML2, IC₅₀: 2.3 μM TRPML3, IC₅₀: 12.5 μM	99.79%
Dihydrocapsaicin			TRPV1			99.93%
GSK1702934A	TRPC3					99.11%
JNJ-28583113		TRPM2				98.82%
SET2			TRPV2, IC₅₀: 0.46 μM			99.78%
Englerin A	hTRPC4, EC₅₀: 11.2 nM hTRPC5, EC₅₀: 7.6 nM					99.50%
TRPM4-IN-2		TRPM4, IC₅₀: 0.16 μM				99.17%
LE135			TRPV1, EC₅₀: 2.5 μM	TRPA1, EC₅₀: 20 μM		99.0%
Acoltremon		TRPM8				99.13%
ML204	TRPC4 TRPC5					98.45%
TRPV2-selective blocker 1			TRPV2, IC₅₀: 6.3 μM			99.84%
Pyr10	TRPC3, IC₅₀: 0.72 μM					99.95%
9-Phenanthrol		TRPM4, IC₅₀: 17 μM				99.61%
RQ-00203078		TRPM8, IC₅₀: 5.3 nM (Rat TRPM8 channels) TRPM8, IC₅₀: 8.3 nM (Human TRPM8 channels)	TRPV4, IC₅₀: 10 μM			99.84%
(rel)-ML-SI3					TRPML1, IC₅₀: 3.1 μM TRPML2, EC₅₀: 3.3 μM TRPML3, IC₅₀: 28.5 μM	98.94%
TRPV3 antagonist 74a			TRPV3			99.85%
Ononetin		TRPM3, IC₅₀: 0.3 μM				99.54%
Larixyl acetate	hTRPC6, IC₅₀: 0.58 μM hTRPC3, IC₅₀: 6.83 μM					99.46%
AP-18				TRPA1, IC₅₀: ~3 μM		99.61%
SOR-C13 TFA			TRPV6, IC₅₀: 14 nM			99.32%
JNJ-17203212			TRPV1			99.94%
Olvanil			TRPV1, EC₅₀: 0.7 nM			≥99.0%
SOR-C13			TRPV6, IC₅₀: 14 nM			99.12%
PF-04745637				TRPA1, IC₅₀: 17 nM		99.97%
PF-05105679		TRPM8, IC₅₀: 103 nM				99.88%
M8-B		TRPM8				99.89%
TRPV1 antagonist 3		TRPM8, IC₅₀: 7.45 μM	hTRPV1, IC₅₀: 2.66 nM			98.97%
ML204 hydrochloride	TRPC4 TRPC5					99.74%
Phenamil methanesulfonate	TRPC3, IC₅₀: 140 nM					98.1%
(1S,2S)-ML-SI3					TRPML1, IC₅₀: 5.9 μM TRPML2, EC₅₀: 2.7 μM TRPML3, EC₅₀: 10.8 μM	99.96%
4α-Phorbol 12,13-didecanoate			TRPV4			99.30%
SOR-C13 acetate			TRPV6, IC₅₀: 14 nM			98.56%
Capsiate			TRPV1			99.85%
AS1269574				TRPA1		99.84%
MDR-652			hTRPV1, Ki: 11.4 nM rTRPV1, Ki: 23.8 nM hTRPV1, EC₅₀: 5.05 nM rTRPV1, EC₅₀: 93 nM			99.02%
MSP-3			TRPV1, EC₅₀: 0.87 μM			98.53%
N-Arachidonyldopamine			TRPV1, EC₅₀: ~50 nM			98.36%
Chrysin 6-C-glucoside 8-C-arabinoside			TRPV1			98.55%
Artepillin C				TRPA1, : 1.8 μM		98.28%
Chembridge-5861528				TRPA1, IC₅₀: 14.3 μM (allyl isothiocyanate-evoked TRPA1 response) TRPA1, IC₅₀: 18.7 μM (4-HNE-evoked TRPA1 response)		99.12%
(R)-Methanandamide			TRPV1			99.61%
JW-65	TRPC3					99.05%
17(R)-Resolvin D1			TRPV3, IC₅₀: 398 nM			99.1%
N-Arachidonoyl Taurine			TRPV1, EC₅₀: 28 μM TRPV4, Ki: 21 μM			99.0%
1,4-Cineole		TRPM8		TRPA1
Vanillyl butyl ether		TRPM8	TRPV1			99.67%
Libvatrep			TRPV1			99.54%
TRPA1-IN-2				TRPA1, IC₅₀: 0.04 μM		99.82%
RN-1665			hTRPV4, IC₅₀: 0.26 μM rTRPV4, IC₅₀: 0.39 μM			99.93%
GFB-8438	hTRPC5, IC₅₀: 0.18 μM hTRPC4, IC₅₀: 0.29 μM rTRPC5, IC₅₀: 0.18 μM					99.74%
D-erythro-Sphingosine hydrochloride		TRPM3				99.87%
L687	TRPC3 TRPC6 TRPC7					99.49%
TRPM7-IN-1		TRPM7/ChaK1				98.83%
Protokylol hydrochloride			TRPV1
TRPV4-IN-5			TRPV4, IC₅₀: 0.46 μM			98.77%
Dihydrocapsiate			TRPV1			99.33%
TRPM8-IN-1		TRPM8, IC₅₀: <5 μM				99.44%
ABT-102			TRPV1			98.50%
V116517			TRPV1
Ricorfotide vedotin			TRPV6
TRPM2-IN-2		TRPM2, IC₅₀: 0.66 μM
TRPV4 antagonist 4			TRPV4, IC₅₀: 22.65 nM
AMG9678				TRPA1, IC₅₀: 0.6 μM
ABT-116			TRPV1
1,4-Cineole (Standard)		TRPM8		TRPA1
TRPV1 antagonist 11			TRPV1, IC₅₀: 29.3 nM
TRPC5-IN-6	TRPC5
ZA10		TRPM2, IC₅₀: 8.1 μM
TRPV1-IN-2				TRPA1
TRPC4/5-IN-1	TRPC5, IC₅₀: 0.54 μM TRPC4, IC₅₀: 2.06 μM
TRPC antagonist 1	TRPC3, IC₅₀: 2.4 μM TRPC4, IC₅₀: 12.2 μM TRPC5, IC₅₀: 7.6 μM TRPC6, IC₅₀: 2.9 μM TRPC7, IC₅₀: 3.4 μM
TRPV1/CB2 agonist 1			TRPV1, EC₅₀: 26.8 μM
L-R4W2 TFA			TRPV1, IC₅₀: 0.1 μM
JTS-653			TRPV1
TRPV4-KCa2.3 modulator 1			TRPV4
CMP233		TRPM4, IC₅₀: 0.15 μM
FAAH/TRPV1 blocker-1			TRPV1, IC₅₀: 94.9 μM
AAL-149		TRPM7/ChaK1, IC₅₀: 1.081 μM
SA-13353			TRPV1
TRPM8 antagonist 4		TRPM8, IC₅₀: 42.3 nM
DFL23448		TRPM8
Artepillin C (Standard)				TRPA1, : 1.8 μM
TRPV1 antagonist 5			TRPV1
ZQMT-10				TRPA1, Ki: 1.04 μM
Methyl kakuol				TRPA1
AMG8788				TRPA1, IC₅₀: 1 μM
L-R4W2			TRPV1, IC₅₀: 0.1 μM
MK-2295			TRPV1
TRPM8 antagonist 4 prodrug		TRPM8
GRC-6211			TRPV1
TRPV1 antagonist 10		TRPM8, IC₅₀: 6.47 μM	TRPV1, IC₅₀: 36.47 nM TRPV3, IC₅₀: >100 μM TRPV4, IC₅₀: >100 μM	TRPA1, IC₅₀: >100 μM
Polygodial pyridazine			TRPV1
ZA18		TRPM2, IC₅₀: 6.2 μM
TRPC5-IN-4	TRPC5, IC₅₀: 14.07 nM TRPC4, IC₅₀: 65 nM
TRPC4/5-IN-3	TRPC4, IC₅₀: 3.6 nM TRPC5, IC₅₀: 5.5 nM
TRPC5-IN-5	TRPC5, IC₅₀: 1.28 μM
TRPA1-IN-3				TRPA1		99.66%
TRPV6-IN-1			TRPV6

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