TRP Channel Inhibitors

TRPC

TRPM

TRPV

TRPA

TRPML

TRP Channel Ligands, Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	TRPC	TRPM	TRPV	TRPA	TRPML	Purity
Rosiglitazone	TRPC5, EC₅₀: 30 μM					99.94%
GSK1016790A			TRPV4			99.79%
Anandamide			TRPV1			≥99.0%
SB-366791			hTRPV1, IC₅₀: 5.7 nM			98.11%
ML-SI3					TRPML1, IC₅₀: 4.7 μM	99.91%
CIM0216		TRPM3				99.94%
Icilin		TRPM8				99.26%
JNJ-28583113		TRPM2				98.82%
Dihydrocapsaicin			TRPV1			99.93%
SET2			TRPV2, IC₅₀: 0.46 μM			99.78%
GSK1702934A	TRPC3					99.11%
(1R,2R)-ML-SI3					TRPML1, IC₅₀: 1.6 μM TRPML2, IC₅₀: 2.3 μM TRPML3, IC₅₀: 12.5 μM	99.79%
LE135			TRPV1, EC₅₀: 2.5 μM	TRPA1, EC₅₀: 20 μM		≥99.0%
ML204	TRPC4 TRPC5					98.45%
TRPM4-IN-2		TRPM4, IC₅₀: 0.16 μM				99.17%
(rel)-ML-SI3					TRPML1, IC₅₀: 3.1 μM TRPML2, EC₅₀: 3.3 μM TRPML3, IC₅₀: 28.5 μM	99.81%
Pyr10	TRPC3, IC₅₀: 0.72 μM					99.95%
Acoltremon		TRPM8				99.13%
9-Phenanthrol		TRPM4, IC₅₀: 17 μM				99.61%
TRPV2-selective blocker 1			TRPV2, IC₅₀: 6.3 μM			99.84%
RQ-00203078		TRPM8, IC₅₀: 5.3 nM (Rat TRPM8 channels) TRPM8, IC₅₀: 8.3 nM (Human TRPM8 channels)	TRPV4, IC₅₀: 10 μM			99.84%
SOR-C13 TFA			TRPV6, IC₅₀: 14 nM			99.18%
Larixyl acetate	hTRPC6, IC₅₀: 0.58 μM hTRPC3, IC₅₀: 6.83 μM					99.46%
AP-18				TRPA1, IC₅₀: ~3 μM		99.61%
TRPV3 antagonist 74a			TRPV3			99.85%
Ononetin		TRPM3, IC₅₀: 0.3 μM				99.54%
PF-04745637				TRPA1, IC₅₀: 17 nM		99.97%
JNJ-17203212			TRPV1			99.94%
Capsiate			TRPV1			99.85%
Olvanil			TRPV1, EC₅₀: 0.7 nM			≥99.0%
TRPV1 antagonist 3		TRPM8, IC₅₀: 7.45 μM	hTRPV1, IC₅₀: 2.66 nM			99.30%
ML204 hydrochloride	TRPC4 TRPC5					99.74%
Phenamil methanesulfonate	TRPC3, IC₅₀: 140 nM					98.1%
M8-B		TRPM8				99.89%
SOR-C13 acetate			TRPV6, IC₅₀: 14 nM			98.56%
SOR-C13			TRPV6, IC₅₀: 14 nM			98.56%
(1S,2S)-ML-SI3					TRPML1, IC₅₀: 5.9 μM TRPML2, EC₅₀: 2.7 μM TRPML3, EC₅₀: 10.8 μM	99.68%
AS1269574				TRPA1		99.84%
Chrysin 6-C-glucoside 8-C-arabinoside			TRPV1			99.11%
MDR-652			hTRPV1, Ki: 11.4 nM rTRPV1, Ki: 23.8 nM hTRPV1, EC₅₀: 5.05 nM rTRPV1, EC₅₀: 93 nM			99.02%
MSP-3			TRPV1, EC₅₀: 0.87 μM			98.53%
Chembridge-5861528				TRPA1, IC₅₀: 14.3 μM (allyl isothiocyanate-evoked TRPA1 response) TRPA1, IC₅₀: 18.7 μM (4-HNE-evoked TRPA1 response)		99.76%
Vanillyl butyl ether		TRPM8	TRPV1			99.67%
JW-65	TRPC3					99.05%
TRPA1-IN-2				TRPA1, IC₅₀: 0.04 μM		99.82%
N-Arachidonyldopamine			TRPV1, EC₅₀: ~50 nM			98.36%
(R)-Methanandamide			TRPV1
Libvatrep			TRPV1			99.54%
RN-1665			hTRPV4, IC₅₀: 0.26 μM rTRPV4, IC₅₀: 0.39 μM			99.93%
N-Arachidonoyl Taurine			TRPV1, EC₅₀: 28 μM TRPV4, Ki: 21 μM			≥99.0%
Artepillin C				TRPA1, : 1.8 μM
GFB-8438	hTRPC5, IC₅₀: 0.18 μM hTRPC4, IC₅₀: 0.29 μM rTRPC5, IC₅₀: 0.18 μM					99.74%
D-erythro-Sphingosine hydrochloride		TRPM3
L687	TRPC3 TRPC6 TRPC7
TRPV4-IN-5			TRPV4, IC₅₀: 0.46 μM
TRPM7-IN-1		TRPM7/ChaK1
Dihydrocapsiate			TRPV1			99.33%
17(R)-Resolvin D1			TRPV3, IC₅₀: 398 nM			99.1%
ABT-102			TRPV1
V116517			TRPV1
CBP-1008			TRPV6
TRPV4 antagonist 4			TRPV4, IC₅₀: 22.65 nM
AMG9678				TRPA1, IC₅₀: 0.6 μM
TRPV1 antagonist 11			TRPV1, IC₅₀: 29.3 nM
TRPC4/5-IN-2	TRPC5
TRPV1-IN-2				TRPA1
TRPC4/5-IN-1	TRPC5, IC₅₀: 0.54 μM TRPC4, IC₅₀: 2.06 μM
TRPC antagonist 1	TRPC3, IC₅₀: 2.4 μM TRPC4, IC₅₀: 12.2 μM TRPC5, IC₅₀: 7.6 μM TRPC6, IC₅₀: 2.9 μM TRPC7, IC₅₀: 3.4 μM
GSK2220691			TRPV4
TRPV1/CB2 agonist 1			TRPV1, EC₅₀: 26.8 μM
L-R4W2 TFA			TRPV1, IC₅₀: 0.1 μM
JTS-653			TRPV1
CMP233		TRPM4, IC₅₀: 0.15 μM
FAAH/TRPV1 blocker-1			TRPV1, IC₅₀: 94.9 μM
AAL-149		TRPM7/ChaK1, IC₅₀: 1.081 μM
Xeniafaraunol A		TRPM7/ChaK1
Artepillin C (Standard)				TRPA1, : 1.8 μM
TRPV1 antagonist 5			TRPV1
ZQMT-10				TRPA1, Ki: 1.04 μM
Methyl kakuol				TRPA1
AMG8788				TRPA1, IC₅₀: 1 μM
L-R4W2			TRPV1, IC₅₀: 0.1 μM
MK-2295			TRPV1
TRPV1 antagonist 10		TRPM8, IC₅₀: 6.47 μM	TRPV1, IC₅₀: 36.47 nM TRPV3, IC₅₀: >100 μM TRPV4, IC₅₀: >100 μM	TRPA1, IC₅₀: >100 μM
Polygodial pyridazine			TRPV1
TRPM8-IN-1		TRPM8, IC₅₀: <5 μM
TRPC5-IN-4	TRPC5, IC₅₀: 14.07 nM TRPC4, IC₅₀: 65 nM
TRPC4/5-IN-3	TRPC4, IC₅₀: 3.6 nM TRPC5, IC₅₀: 5.5 nM
TRPC5-IN-5	TRPC5, IC₅₀: 1.28 μM
TRPA1-IN-3				TRPA1
Protokylol hydrochloride			TRPV1
TRPV6-IN-1			TRPV6

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