2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Ambenonium dichloride tetrahydrate

Ambenonium dichloride tetrahydrate  (Synonyms: WIN 8077 dichloride tetrahydrate)

目录号: HY-118533A
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摩尔计算器

Ambenonium (WIN 8077) dichloride tetrahydrate 是一种具有口服活性、可逆的 AChE 抑制剂。Ambenonium dichloride tetrahydrate 抑制 AChE，IC50 为 0.7 nM (hAChE)。Ambenonium dichloride tetrahydrate 能够用于对重症肌无力 (Myasthenia Gravis) 的研究。

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Ambenonium dichloride tetrahydrate Chemical Structure

Ambenonium dichloride tetrahydrate Chemical Structure

CAS No. : 52022-31-8

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Ambenonium dichloride tetrahydrate 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ambenonium (WIN 8077) dichloride tetrahydrate is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride tetrahydrate inhibits human AChE with an IC50 value of 0.7 nM (hAChE)[1][2].

IC50 & Target

IC50: 0.7 nM (hAChE), 7 μM (hBChE)[1]
体外研究
(In Vitro)

Ambenonium dichloride tetrahydrate inhibits Acetyicholinesterase (AChE) in a rapidly reversible method, and shows strong inhibition with inhibition constant Ki of 0.12 nM against hAChE[1].
Ambenonium dichloride tetrahydrate shows inhibitory effect towards BChE with an IC50 value of 7 μM (hBChE)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ambenonium dichloride tetrahydrate 相关抗体:
体内研究
(In Vivo)

Ambenonium dichloride tetrahydrate (6 mg/kg; p.o.; daily; 30-60 d) results an adverse effect on neuromuscular transmission in long-term administration, and induces hypersensitivity to stimulation in myasthenia gravis mice modle[3].
Ambenonium dichloride tetrahydrate (6 mg/kg; p.o.; daily; 14 d) decreases the number of AChR in motorend-plates[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague Dawley rats (weight 250 g) with myasthenia gravis[3]
Dosage: 6 mg/kg
Administration: Oral gavage; daily; 14, 30, 60, 90, 360 days (Stop administration 24 h in advance)
Result: Resulted general activity decreasing and hypersensity to stimulation in rats during day 30-60, but these behaviors disappeared on day 90.
Induced degeneration and simplification of the postsynaptic folds, widening of the synaptic clefts, increased number of the postsynaptic vesicles, and reduction in the number of the AChR in the postsynaptic membrane on day 360.
分子量

680.53

Formula

C28H50Cl4N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ambenonium dichloride tetrahydrate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ambenonium dichloride tetrahydrate52022-31-8WIN 8077 dichloride tetrahydrateCholinesterase (ChE)Myasthenia Gravismotor endplateAcetyicholinesteraseneuromuscular transmissionInhibitorinhibitorinhibit

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