1. Apoptosis
  2. TNF Receptor
  3. AMG-966

AMG-966 是一种靶向 TNFSF15/TL1A & TNFα 的人类双特异性抗体 (bsAb)。AMG 966 可恢复无糖基化 Fc 结构域结合 FcγRIa 和 FcγRIIa 的能力,从而导致抗药抗体 (ADA) 的形成。AMG 966 可用于克罗恩病和溃疡性结肠炎的研究。推荐同型对照:Human IgG1 kappa,Isotype Control (HY-P99001)。

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AMG-966

AMG-966 Chemical Structure

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
1 mg ¥4500
In-stock
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMG-966 is a human bispecific antibody (bsAb) targeting TNFSF15/TL1A & TNFα. AMG 966 restores the ability of the aglycosylated Fc domain to bind to FcγRIa and FcγRIIa, leading to the formation of antidrug antibodies (ADA). AMG-966 can be used in Crohn's disease and Ulcerative colitis research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001)[1].

同型

Human IgG1 kappa

推荐同型对照抗体
反应种属

Human

IC50 & Target

TNFSF15

基因 ID

9966  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
AMG-966
目录号:
HY-P991440
需求量: