2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. GABA Receptor 5-HT Receptor Reactive Oxygen Species (ROS)
  4. Aminochalcone 4AAF

Aminochalcone 4AAF 是一个神经保护剂，通过 GABAA 和 5-HT receptors 发挥抗焦虑作用。Aminochalcone 4AAF 对 5-HT3A 和 5-HT2C 受体具有高选择性，并刺激 5-HT2A 受体的变构行为。Aminochalcone 4AAF 具有降血糖作用，并降低肝脏中活性氧 (ROS) 的水平。Aminochalcone 4AAF 延迟癫痫发作的强直期。Aminochalcone 4AAF 可用于焦虑、高血糖和癫痫的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Aminochalcone 4AAF

Aminochalcone 4AAF Chemical Structure

CAS No. : 38239-51-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Aminochalcone 4AAF 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures[1].

体内研究
(In Vivo)

Aminochalcone 4AAF (20 μL of 0.1-10 mg/mL，口服，单次给药) 显示出抗焦虑和降血糖作用，可逆转成年斑马鱼因蔗糖诱导的焦虑和血糖升高，并延迟癫痫发作的强直期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult zebrafish aged between 90 and 120 days, measuring approximately 3.5 cm in length and weighing approximately 0.4 g[1]
Dosage: 20 μL of 0.1, 0.5, or 10 mg/mL
Administration: p.o. for a single dose
Result: Showed not toxicity to adult zebrafish (LC50 > 1.0 mg/mL).
Exhibited anxiolytic behavior in novel tank test.
Caused a significant impairment of motor function in open field test and spinning task.
Altered the latency time and the number of crossings between the light and dark sides.
Restored the locomotor pattern when pretreated with Flumazenil (HY-B0009) (0.1 mg/mL).
Reduced the time the fish spent in the light area of the aquarium when pretreated with Cyproheptadine (HY-B1622), Pizotifen (HY-B0115), and Granisetron (HY-B0071).
Increased latency time and reduced the number of crossings from the light to the dark.
Prevented hyperglycemia-induced oxidative stress in liver and brain tissues of adult zebrafish (0.5 mg/mL).
Reversed PTZ-induced convulsive behavior in stage three (1.0 mg/mL).
分子量

223.27

Formula

C15H13NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aminochalcone 4AAF 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminochalcone 4AAF38239-51-9GABA Receptor5-HT ReceptorReactive Oxygen Species (ROS)Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorSerotonin Receptor5-hydroxytryptamine ReceptoranxietyhyperglycemiaseizuresInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Aminochalcone 4AAF
目录号：
HY-175263
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z