2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Androgen receptor antagonist 5

Androgen receptor antagonist 5 

目录号: HY-146494
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摩尔计算器

Androgen receptor antagonist 5 (compound 42f) 是一种有效的雄激素受体 (AR) 拮抗剂，IC50 为 6.17 μM。Androgen receptor antagonist 5 可有效损害 AR 核转位，降低细胞核 AR 水平，扰乱 AR 介导的基因调控。Androgen receptor antagonist 5 可抑制前列腺癌细胞 LNCaP 的增殖，并在 LNCaP 异种移植小鼠模型中表现出抗肿瘤活性。Androgen receptor antagonist 5 可用于前列腺癌症的研究。

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Androgen receptor antagonist 5 Chemical Structure

Androgen receptor antagonist 5 Chemical Structure

CAS No. : 2586195-28-8

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Androgen receptor antagonist 5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].

IC50 & Target

IC50: 6.17 μM (AR)[1]
体外研究
(In Vitro)

Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Androgen receptor antagonist 5 相关抗体:
分子量

493.43

Formula

C21H15F4N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Androgen receptor antagonist 5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Androgen receptor antagonist 52586195-28-8Androgen receptor antagonist5Androgen receptor antagonist-5Androgen ReceptorProstate cancerAnticancerAntitumorLNCaPInhibitorinhibitorinhibit

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