2. Anti-infection Apoptosis
  3. Bacterial TNF Receptor
  4. Anti-inflammatory agent 15

Anti-inflammatory agent 15 (化合物 29) 是一种有效的抗结核分枝杆菌和抗炎剂。Anti-inflammatory agent 15 抑制 Mtb H37Rv 和 M299 生长，其 MIC50 (最低抑制浓度 50%) 分别为 2.3 和 7.8 μM。Anti-inflammatory agent 15 通过抑制 iNOS 表达抑制 NO，同时抑制 TNF-α 和 IL-1β 的产生。Anti-inflammatory agent 15 可用于结核病的研究。

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Anti-inflammatory agent 15 Chemical Structure

Anti-inflammatory agent 15 Chemical Structure

CAS No. : 474516-87-5

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Anti-inflammatory agent 15 相关抗体

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  • 生物活性

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生物活性

Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research[1].

IC50 & Target

MIC50: 2.3 ± 1.6 μM (Mtb H37Rv), 7.8 ± 0.8 μM (Mtb M299); IC50: 2.4 ± 0.4 μM (NO)[1]
体外研究
(In Vitro)

Anti-inflammatory agent 15 (compound 29) is active in the reduction of accumulated nitrite, with an IC50 of 71.7 ± 1.1 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 15 相关抗体:
分子量

284.42

Formula

C17H20N2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 15 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 15474516-87-5BacterialTNF ReceptorTumor Necrosis Factor ReceptorTNFRthiourea derivativeantimycobacterialanti-inflammatorylow cytotoxicityTuberculosisTBMtb H37RvMtb M299MycobacteriumbacterialInhibitorinhibitorinhibit

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