VE-Cadherin 抗体 (YA3491)

VE-Cadherin Antibody (YA3491) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VE-Cadherin.

CD144/VE Cadherin 是一种钙依赖性细胞黏附蛋白 (By similarity)。它优先以同源方式在连接细胞中自我相互作用，从而可能促进异质细胞类型的分类 (PubMed:21269602)。该 cadherin 通过控制细胞间连接的凝聚和组织，可能在内皮细胞生物学中发挥重要作用 (By similarity)。它与 alpha-catenin 结合，形成与细胞骨架的连接 (PubMed:10861224)。在内皮细胞中，它通过作为 AMOTL2 和 MAGI1 的细胞连接复合物锚点，在将肌动蛋白纤维耦合到细胞连接中发挥作用 (By similarity)。它与 KRIT1 和 PALS1 协同作用，建立并维持正确的内皮细胞极性和血管腔 (By similarity)。这些效应是通过招募和激活 Par 极性复合物及 RAP1B 介导的 (PubMed:20332120)。它对于 PRKCZ 的激活以及将磷酸化的 PRKCZ、PARD3、TIAM1 和 RAP1B 定位到细胞连接是必需的 (PubMed:20332120)。它与 CTNND1/p120-catenin 结合以控制 CADH5 的内吞作用 (By similarity)。

P33151

Predicted band size: 88 kDa; Observed band size: 130 kDa

affinity purified

Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.

Non-conjugated

Unmodified

AB_3103207

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human

WB: 1:2,000；IF-Cell: 1:100；FC: 1:1,000

WB, ICC/IF, FC

EA.hy926 cell lysates, human lung tissue lysate, human kidney tissue lysate, EA.hy926.

液体

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Synthetic peptide within human VECadherin aa 1-650 / 784.