1. 抗体
  2. 一抗
  3. 多克隆抗体 流式抗体
  4. TERT 抗体

TERT Antibody 是一个兔来源、无偶联标记、抗 TERT 的 IgG 多克隆抗体。

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规格 价格 是否有货 数量
10 μL ¥470 In-stock
50 μL ¥1220 In-stock
100 μL ¥2000 In-stock
250 μL   询价  

* Please select Quantity before adding items.

【WB: 蛋白质免疫印迹; IHC-P: 石蜡切片样本的免疫组织化学; IHC-F: 冰冻切片样本的免疫组织化学; ICC/IF: 细胞免疫荧光; IF-Tissue: 组织免疫荧光; mIHC: 多重荧光免疫组化; IP: 免疫沉淀; ChIP: 染色质免疫沉淀; FC: 流式细胞术; ELISA: 酶联免疫吸附试验】

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

TERT Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TERT.

研究背景

TERT 是端粒酶(telomerase)的催化亚基,该核糖核蛋白复合体在大多数真核生物中对染色体末端的复制至关重要。它在祖细胞(progenitor cells)和癌细胞中具有活性,而在正常体细胞(somatic cells)中无活性或活性极低。作为端粒酶全酶复合体(holoenzyme complex)的核心组分,TERT 通过逆转录酶(reverse transcriptase)功能,以自身 RNA 组件的模板序列为引导,在染色体末端添加 TTAGGG 重复单元,从而延长端粒(telomeres)。其催化周期包括引物结合、延伸及模板边界到达后的产物释放。TERT 对含 2-3 个端粒重复的底物活性更高,其功能受复合体关联蛋白、分子伴侣(chaperones)及翻译后修饰调控,同时参与 Wnt 信号通路调节,在衰老(aging)和抗凋亡(antiapoptosis)中起关键作用。

基因 ID
蛋白数据库
中文名
端粒酶反转录酶抗体
同用名
Telomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; Telomerase reverse transcriptase; Telomerase Catalytic Subunit; Telomerase-associated protein 2; TERT_HUMAN.
分子量

Predicted band size: 125 kDa; Observed band size: 125 kDa

纯度

affinity purified

亚细胞定位

Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1\/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.

偶联

Non-conjugated

修饰

Unmodified

RRID
产品类别

Primary Antibody; Rabbit Polyclonal Antibody

克隆性

Polyclonal

宿主

Rabbit

反应物种

Human, Mouse, Rat,

推荐稀释比例

WB: 1:500-2000; ELISA: 1:5000-10000; IHC-P: 1:100-500; IHC-F: 1:100-500; FC: 1μg/Test;ICC: 1:100; IF: 1:100-500

应用

WB, ELISA, IHC-P, IHC-F, FC, ICC/IF,

性状

液体

组分

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

运输条件

Shipping with blue ice.

同型

IgG

敏感性

Endogenous

免疫原

KLH conjugated synthetic peptide derived from human TERT: 601-750/1132

数据库
文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TERT Antibody
目录号:
HY-P81110
需求量: