2. Apoptosis
  3. Ferroptosis
  4. Anticancer agent 147

Anticancer agent 147 (compound 6j) 是槐定碱 (HY-N1373) 的衍生物，是一种铁死亡 (Ferroptosis) 诱导剂。Anticancer agent 147 可促进细胞内 Fe2+、活性氧 (ROS) 和 MDA 的积累，并能够增加 ER 应激、上调激活转录因子 ATF3 的表达。Anticancer agent 147 在体外和体内具有良好的抗肝癌作用。

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Anticancer agent 147 Chemical Structure

Anticancer agent 147 Chemical Structure

CAS No. : 2241283-11-2

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Anticancer agent 147 相关抗体

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  • 生物活性

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生物活性

Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].

分子量

578.58

Formula

C32H40BrN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 147 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1472241283-11-2Anticancer agent147Anticancer agent-147FerroptosisFe2+reactive oxygen speciesROSMDAER stressliver cancerInhibitorinhibitorinhibit

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