2. Anti-infection
  3. Fungal
  4. Antifungal agent 31

Antifungal agent 31 (化合物 12) 是一种口服有效的具有吡咯三嗪酮支架的三唑类抗真菌剂。Antifungal agent 31 对念珠菌和丝状真菌具有一定的抗真菌活性。Antifungal agent 31 显著降低两种致死性全身感染小鼠模型的死亡率和肾脏真菌负担。

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Antifungal agent 31 Chemical Structure

Antifungal agent 31 Chemical Structure

CAS No. : 2077083-94-2

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Antifungal agent 31 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections[1].

分子量

492.48

Formula

C25H22F2N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antifungal agent 31 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 312077083-94-2Antifungal agent31Antifungal agent-31Fungalorally activeAntifungal agentsAzolesCandidaFilamentous fungiInvasive fungal infectionsIFIspyrrolotriazinone scaffoldInhibitorinhibitorinhibit

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