2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-13

Antileishmanial agent-13 是一种喹啉-靛蓝杂交物，可作为抗利什曼病试剂，抑制 L. Major Leishmania 株系。Antileishmanial agent-13 通过抗叶酸机制获得其抗利什曼病活性。Antileishmanial agent-13 对前鞭毛体和无鞭毛体均具有较强的抑制作用，IC50 分别为 0.604 μM 和 0.508 μM。

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Antileishmanial agent-13 Chemical Structure

Antileishmanial agent-13 Chemical Structure

CAS No. : 853725-86-7

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Antileishmanial agent-13 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].

IC50 & Target

Leishmania

 

体外研究
(In Vitro)

Antileishmanial agent-13 (compound 4e) shows promising in vitro activity against the promastigote superior to Miltefosine (HY-13685) (IC50=7.8976 µM)[1].
Antileishmanial agent-13 (2 μM; 48 h) shows antileishmanial activity mostly attributing to the anti-folate mechanism, via inhibiting DHFR-TS and PTR1[1].
Antileishmanial agent-13 (0-100 μM; 72 h) has low cytotoxicity against African green monkey kidney cells (VERO cells) with CC50 value of 155.8 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-13 相关抗体:
分子量

401.64

Formula

C17H10BrClN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antileishmanial agent-13 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-13853725-86-7Antileishmanial agent13Antileishmanial agent 13Parasitequinoline-isatin hybridL. Major LeishmaniapromastigoteamastigoteInhibitorinhibitorinhibit

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