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  4. Antimalarial agent 25

Antimalarial agent 25 是一种口服有效的、具有抗疟活性的 1,4-萘醌衍生物。Antimalarial agent 25 显示出对 P. falciparum 的细胞毒性。Antimalarial agent 25 在体内抑制 P. burghei 诱导的寄生虫血症。

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Antimalarial agent 25 Chemical Structure

Antimalarial agent 25 Chemical Structure

CAS No. : 2944456-41-9

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Antimalarial agent 25 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo[1].

体外研究
(In Vitro)

Antimalarial agent 25 (compound 8) 抑制 P. falciparum 的 IC50 为 4.2 μM，而对哺乳动物细胞的CC50 分别为 289.2 μM (HepG2) 和 400.6 μM (Vero)[1]。
Antimalarial agent 25 (compound 8) (15.62-1000 μM; 2 小时) 在未受感染的人类红细胞中，15.6 至250 μM 的浓度显示出低于 40% 的溶血活性[1]。
Antimalarial agent 25 (compound 8) (30-0.411 μg/mL; 48 h) 导致 W2 strain of P. falciparum 的细胞质完全退化，膜的完整性丧失等形态的变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 25 相关抗体:

Cell Viability Assay[1]

Cell Line: W2 strain of P. falciparum (CQ-resistant)
Concentration: 30 - 0.411 μg/mL
Incubation Time: 48 h
Result: Presented completely degraded cytoplasm with loss of membrane integrity, dense cytoplasm with some possible undefined organelles in degenerating stage, and a possible deteriorated food vacuole.
体内研究
(In Vivo)

Antimalarial agent 25 (30 mg/kg; PO; QID) 可增强伯氏疟原虫小鼠的抗疟活性[1]。 Antimalarial agent 25 (300 mg/kg; 口服; 单次剂量) 在雌性小鼠中无明显的病理改变以及组织病理学损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice infected with Plasmodium berghei ANKA[1]
Dosage: 30 mg/kg
Administration: Oral administration; for 4 consecutive days
Result: Partly reduced P. berghei infection.
Parasitemia decreased by 33% on the seventh day (post-treatment).
分子量

374.39

Formula

C21H18N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 25 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antimalarial agent 252944456-41-9Antimalarial agent25Antimalarial agent-25ParasiteMalariaplasmodium1,2,3-Triazoleamino-naphthoquinoneparasitemiaInhibitorinhibitorinhibit

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