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  4. Antimalarial agent 26

Antimalarial agent 26 是一种口服有效的、具有抗疟活性的 1,4-萘醌衍生物。Antimalarial agent 26 显示出对恶性疟原虫 (P. falciparum) 的细胞毒性和对高于哺乳动物细胞系的选择性。Antimalarial agent 26 在体内抑制 P. burghei 诱导的寄生虫血症。

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Antimalarial agent 26 Chemical Structure

Antimalarial agent 26 Chemical Structure

CAS No. : 2299199-56-5

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Antimalarial agent 26 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo[1].

体外研究
(In Vitro)

Antimalarial agent 26 (compound 11) 抑制 P. falciparum 的 IC50 为 2.7 μM，而对哺乳动物细胞的 CC50 分别为 440.9 μM (HepG2) 和 1336 μM (Vero)[1]。
Antimalarial agent 26 (1000-15.62 μM；2 小时) 在浓度为 250 至 15.6 μM 时显示溶血活性低于 40%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 26 相关抗体:
体内研究
(In Vivo)

Antimalarial agent 26 (compound 11) (30 mg/kg；口服；每天一次，连续 4 天) 在雌性白化病瑞士小鼠中显示出抗疟活性[1]。
Antimalarial agent 26 (300 mg/kg；口服；单次剂量) 在雌性小鼠导致肝细胞损伤的病理损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female albino swiss mice[1]
Dosage: 300 mg/kg
Administration: PO; single dose
Result: Presented necrosis of hepatocytes in moderate to severe degrees, acidophilic cytoplasm with macro vacuoles and micro steatosis, granular degeneration and congestion of the lobular center vein and hepatic portal vein.
In the kidney, Resulted an atrophic glomerulus was observed with congested capillaries, reduction of mesangial cells and podocytes with discrete thickening of the basal membrane.
分子量

366.41

Formula

C20H22N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antimalarial agent 26 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 262299199-56-5Antimalarial agent26Antimalarial agent-26ParasiteP. FalciparumP. burgheiparasitemia1,4-naphthoquinonesInhibitorinhibitorinhibit

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