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Antitumor agent-19 是一种靶向肿瘤相关巨噬细胞 (TAMs) 的抗肿瘤药,可用作有效的 TAMs 调节剂。Antitumor agent-19 在 RAW 264.7 细胞和 BMDM 细胞中的 EC50 值分别为 17.18 µM 和 18.87 µM。

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Antitumor agent-19 Chemical Structure

Antitumor agent-19 Chemical Structure

CAS No. : 2379727-90-7

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1 mg ¥2207
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-19 is an antitomor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator. The EC50 values of Antitumor agent-19 in the RAW 264.7 cells and the BMDM cells are 17.18 μM and 18.87 μM, respectively[1].

IC50 & Target

tumor-associated macrophages (TAMs)[1]

体外研究
(In Vitro)

Antitumor agent-19 (Compound 23a; 10-50 µM; 1 hour; RAW 264.7 cells) treatment effectively induces the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner. Antitumor agent-19 is found to dose-dependently repolarize TAMs from M1 (anti-tumor) and M2 (pro-tumor)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: RAW 264.7 cells
Concentration: 10 µM, 20 µM, or 50 µM
Incubation Time: 1 hour
Result: Induced the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner.
体内研究
(In Vivo)

Antitumor agent-19 (Compound 23a; 5 mg/kg; intraperitoneal injection; every other day; for 30 days; C57BL/6 female mice) is capable of remarkably inhibiting tumor growth of the LLC mouse model. Moreover, the synergy of Antitumor agent-19 with anti-PD-1 antibody has more superior antineoplastic effects than the exclusive use of either in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-to eight-week-old C57BL/6 female mice with lewis lung cancer cells (LLC)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; every other day; for 30 days
Result: Remarkably inhibited tumor growth of the LLC mouse model.
分子量

487.90

Formula

C24H21ClF3N5O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Antitumor agent-19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Antitumor agent-19
目录号:
HY-128776
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