2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-53

Antitumor agent-53 是一种有效的抗癌剂。Antitumor agent-53 诱导细胞周期停滞在 G2/M 期。Antitumor agent-53 抑制 PI3K/AKT 信号通路并诱导 HGC-27 细胞凋亡 (apoptosis)。Antitumor agent-53 具有研究胃肠道肿瘤的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Antitumor agent-53 Chemical Structure

Antitumor agent-53 Chemical Structure

CAS No. : 2757145-67-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Antitumor agent-53 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors[1].

体外研究
(In Vitro)

Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 µM; 72 h) shows anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells[1].
Antitumor agent-53 (0.15, 0.3, 0.6 µM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner[1].
Antitumor agent-53 (100, 200 µM) shows a certain inhibitory activity against Topo I at 200 μM[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells[1].
Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner[1].
Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-53 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells
Concentration: 0, 0.22, 0.67, 2, 6, 18 µM
Incubation Time: 72 h
Result: Showed anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells.

Cell Cycle Analysis[1]

Cell Line: HGC-27, HT-29 cells
Concentration: 0.1, 0.3, 0.9 μM
Incubation Time: 24 h
Result: Cells were arrest at the G2/M phase.

Apoptosis Analysis[1]

Cell Line: HGC-27, HT-29 cells
Concentration: 0.1, 0.3, 0.9, 2.7 μM
Incubation Time: 24 h
Result: Induced the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: HGC-27 cells
Concentration: 0.1, 0.3, 0.9 μM
Incubation Time: 24 h
Result: Suppressed the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells.
分子量

383.42

Formula

C24H18FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-53 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-532757145-67-6Antitumor agent53Antitumor agent 53ApoptosisPI3K/AKTapoptosisHGC-27HT-29G2/Mgastrointestinalanti-tumorInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antitumor agent-53
目录号：
HY-146743
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z