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  4. Antitumor agent-67

Antitumor agent-67 (compound 3) 是一种有效的抗肿瘤剂。Antitumor agent-67 对癌细胞具有较高的选择性毒性，对正常细胞的损伤较低。Antitumor agent-67 可被 NQO1 激活，有效释放鬼臼毒素 (Podophyllotoxin)，杀死肿瘤细胞。Antitumor agent-67 在 HepG2 异种移植肿瘤模型中有明显的肿瘤抑制作用，且无明显毒性作用。

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Antitumor agent-67 Chemical Structure

Antitumor agent-67 Chemical Structure

CAS No. : 2820146-10-7

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Antitumor agent-67 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity[1].

IC50 & Target

NQO1[1]
体外研究
(In Vitro)

Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC50s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-67 相关抗体:
分子量

809.85

Formula

C45H47NO13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-67 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-672820146-10-7Antitumor agent67Antitumor agent 67OthersAnticancerAntiproliferativeHepG2A549LO2NQO1Inhibitorinhibitorinhibit

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