1. Apoptosis
  2. Apoptosis
  3. Apoptosis inducer 4

Apoptosis inducer 4 (Compound 12b) 是一种具有抗癌活性的细胞凋亡 (apoptosis) 诱导剂。

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Apoptosis inducer 4 Chemical Structure

Apoptosis inducer 4 Chemical Structure

CAS No. : 2408050-83-7

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  • 生物活性

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生物活性

Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities[1].

体外研究
(In Vitro)

Apoptosis inducer 4 (Compound 12b) (0-50 µM, 72 h) shows antiproliferative activities against cancer cells without obvious cytotoxicity against normal cells[1].
Apoptosis inducer 4 (0-2 µM, 48 h) causes cell cycle arrest at S phase in K562 cells and G1 phase in HepG2 cells[1].
Apoptosis inducer 4 (0-4 µM, 24 and 48 h) induces pyknosis in K562 cells, and induces mitochondrial membrane potentials decline[1].
Apoptosis inducer 4 (0-2 µM, 72 h) induces apoptosis in K562 and HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Showed antiproliferative activities with IC50 values of 2.57 ± 0.12, 16.15 ± 1.02, 5.81 ± 1.17, 12.94 ± 0.88, 0.95 ± 0.06, 17.59 ± 0.93 and >50 µM against HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC cells, respectively.

Cell Cycle Analysis[1]

Cell Line: K562 and HepG2 cells
Concentration: K562 and HepG2 cells
Incubation Time: 48 h
Result: Arrested K562 cell cycle at S phase and HepG2 cell at G1 phase.

Apoptosis Analysis[1]

Cell Line: K562 and HepG2 cells
Concentration: K562 and HepG2 cells
Incubation Time: 72 h
Result: Apoptotic ratios of K562 and HepG2 cells obviously increased in a concentration-dependent manner.
分子量

815.02

Formula

C41H50O11S3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Apoptosis inducer 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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