1. GPCR/G Protein
  2. LPL Receptor
  3. ASP1126

ASP1126 

目录号: HY-125881
产品使用指南

ASP1126 是选择性的、具有口服活性的鞘氨醇1-磷酸 (S1P) 的激动剂,对 hS1P1 和 hS1P3EC50 值分别为 7.12 nM 和 517 nM。ASP1126可减少外周血淋巴细胞、初代T细胞、中央记忆T细胞和效应记忆T细胞的数量。ASP1126具有较好的安全性,具有应用于临床移植的潜力。

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ASP1126 Chemical Structure

ASP1126 Chemical Structure

CAS No. : 1228580-11-7

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Description

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].

IC50 & Target

EC50: 7.12 nM (hS1P1), 517 nM (hS1P3)[1].

In Vivo

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time[1].

Animal Model: ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively[1].
Dosage: 0.2 mg/kg, 1 mg/kg, 5 mg/kg.
Administration: Orally once daily for 14 days.
Result: Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
Molecular Weight

581.93

Formula

C₂₆H₂₆ClF₆NO₅

CAS No.

1228580-11-7

SMILES

O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ASP1126
目录号:
HY-125881
需求量:

ASP1126

Cat. No.: HY-125881