2. Immunology/Inflammation Apoptosis
  3. NO Synthase TNF Receptor Interleukin Related
  4. Asperflavin

Asperflavin 是一种可以由海洋真菌 Eurotium amstelodami 产生的抗炎化合物。Asperflavin 在 LPS (HY-D1056) 处理的 RAW 264.7 细胞中，可抑制 NO、PGE2 和促炎细胞因子的产生，以及诱导型 NOS (iNOS) 表达。Asperflavin 可用于炎症性疾病的研究。

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Asperflavin Chemical Structure

Asperflavin Chemical Structure

CAS No. : 1415764-41-8

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Asperflavin 相关抗体

Top Publications Citing Use of Products

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nNOS iNOS eNOS

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asperflavin is an anti-inflammatory compound that can be produced by the marine fungus Eurotium amstelodami. Asperflavin inhibits the production of NO, PGE2, and proinflammatory cytokines, as well as the expression of inducible NOS (iNOS) in RAW 264.7 cells treated with LPS (HY-D1056). Asperflavin can be used in the study of inflammatory diseases[1].

IC50 & Target[1]

iNOS

 

IL-6

 

IL-1β

 

TNF-α

 

体外研究
(In Vitro)

Asperflavin (0-200 μM，24 小时) 在 LPS 处理下，不会改变 RAW 264.7 细胞的细胞活力[1]。

Asperflavin (0-200 μM，24 小时) 可抑制 LPS 处理的 RAW 264.7 细胞中 NO 和 PGE2 的产生[1]。

Asperflavin (0-200 μM，24 小时) 可抑制 LPS 处理的 RAW 264.7 细胞中 iNOS 的表达，但不会降低 COX-2 的表达[1]。

Asperflavin (0-200 μM，24 小时) 可降低 LPS 处理的 RAW 264.7 细胞中 TNF-α、IL-1β 和 IL-6 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Asperflavin 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS-Stimulated (1 μg/mL) RAW 264.7 cells
Concentration: 50 μM, 100 μM, 200 μM
Incubation Time: 24 h
Result: Inhibited the expression of iNOS but did not reduce the expression of COX-2.

ELISA Assay[1]

Cell Line: LPS-Stimulated (1 μg/mL) RAW 264.7 cells
Concentration: 50 μM, 100 μM, 200 μM
Incubation Time: 24 h
Result: Reduced the production of TNF-α, IL-1β, and IL-6 at a concentration of 200 μM.
Reduced TNF-α, IL-6 levels without changing IL-1β levels at concentrations of 100 μM.
Reduced the production of TNF-α, did not change IL-1β, IL-6 production at a concentration of 50 μM.
分子量

288.30

Formula

C16H16O5
CAS 号
结构分类
初始来源

Aspergillus sp. EGF15-0-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Asperflavin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asperflavin1415764-41-8NO SynthaseTNF ReceptorInterleukin RelatedNitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRILAnti-inflammatoryRAW 264.7 cellsInhibitorinhibitorinhibit

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