2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. ATR-258

ATR-258 是一种 GRK2 偏向的 β2AR 部分激动剂。ATR-258 是一种竞争性 β1AR 拮抗剂，在 10 μM 浓度下对 β3AR 表现出较弱的部分激动活性。ATR-258 可促进肥胖小鼠的血糖控制，减少脂质堆积，且副作用较小。ATR-258 可用于 2 型糖尿病 (T2DM) 研究。

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ATR-258 Chemical Structure

ATR-258 Chemical Structure

CAS No. : 2301983-88-8

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ATR-258 相关抗体

Top Publications Citing Use of Products

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATR-258 is a GRK2-biased β2AR partial agonist. ATR-258 is a competitive β1AR antagonist and shows weak partial agonist activity at β3AR at 10 μM. ATR-258 promotes glucose control and decreases lipid accumulation in obese mice with reduced side effects. ATR-258 can be used for T2DM research[1].

IC50 & Target[1]

Beta-2 adrenergic receptor

 

分子量

212.26

Formula

C11H17FN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATR-258 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-2582301983-88-8ATR258ATR 258Adrenergic ReceptorBeta ReceptorType 2 diabetesobesityT2DMglucoseInhibitorinhibitorinhibit

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产品名称：
ATR-258
目录号：
HY-176742
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