2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ATX-IN-3

ATX-IN-3 是一种口服有效的自分泌运动因子 (ATX) 抑制剂，其 IC50 为 46 nM。ATX-IN-3 能够改善小鼠肺纤维化模型中的肺纤维化，显著减少胶原沉积。ATX-IN-3 具有良好的代谢稳定性和类药性。ATX-IN-3 可用于特发性肺纤维化 (IFP) 的研究。

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ATX-IN-3

ATX-IN-3 Chemical Structure

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     可免费申领三个不同产品的试用装。

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Customer Review

ATX-IN-3 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATX-IN-3 is an orally active autotaxin (ATX) inhibitor with an IC50 of 46 nM. ATX-IN-3 certainly reduces collagen deposition and ameliorates lung fibrosis in the pulmonary fibrosis mouse model. ATX-IN-3 has good metabolic stability and drug-like properties. ATX-IN-3 can used for the study of idiopathic pulmonary fibrosis (IFP)[1].

体外研究
(In Vitro)

ATX-IN-3 (Compound 12) 具有良好的类药特性，包括在大鼠肝微粒体中良好的代谢稳定性 (t1/2 = 73.06 min，Clint = 18.97 μL/min/mg)，较高的药物相似性评分 (1.24) 和配体亲脂效率 (LLE) 值 (2.98) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATX-IN-3 相关抗体:
体内研究
(In Vivo)

ATX-IN-3 (Compound 12) (60 mg/kg，口服灌胃，每日一次，连续 21 天) 可抑制 Bleomycin (HY-108345) 诱导的小鼠肺纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin induced IPF model established in male C57BL/6 mice (6-8 weeks)[1]
Dosage: 60 mg/kg
Administration: Oral gavage (i.g.), once daily for 21 days
Result: Significantly improved fibrosis indicators, reduced collagen deposition and inflammatory infiltration.
Did not change heart, liver, and kidney indexes, and ALT, AST and other indicators are all within the normal range.
分子量

526.56

Formula

C29H27FN6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATX-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATX-IN-3Phosphodiesterase (PDE)Idiopathic pulmonary fibrosis (IFP)Bleomycinmice modelDrug-like propertiesInhibitorinhibitorinhibit

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产品名称：
ATX-IN-3
目录号：
HY-175537
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