2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ATX inhibitor 12

ATX inhibitor 12 (化合物 20) 是一种口服有效的 ATX 抑制剂，其 IC50 为 1.72 nM。ATX inhibitor 12 在 C57Bl/6J 小鼠中口服剂量为 60 mg/kg 时，可有效缓解肺结构损伤，减少纤维化病变。ATX inhibitor 12 可用于特发性肺纤维化 (IPF) 的研究。

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ATX inhibitor 12 Chemical Structure

ATX inhibitor 12 Chemical Structure

CAS No. : 2771312-16-2

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ATX inhibitor 12 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

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  • 参考文献

生物活性

ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research[1].

IC50 & Target

Autotaxin

1.72 nM (IC50)

分子量

515.62

Formula

C30H34FN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATX inhibitor 12 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

ATX inhibitor 122771312-16-2ATX inhibitor12ATX inhibitor-12Phosphodiesterase (PDE)Imidazo[1,2-a]pyridineHybrid strategyUreaAnti-fibrosisAutotaxin (ATX)benzylamine derivativephosphodiesterasidiopathic pulmonary fibrosis (IPF)orally activeInhibitorinhibitorinhibit

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