2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. AURKA-IN-3

AURKA-IN-3 (Compound AL8) 是一种不可逆的共价型 Aurora 激酶 A (AURKA) 抑制剂，IC50 值为 23.0 nM。AURKA-IN-3 能抑制由 AURKA 介导的 cAMP 信号通路和磷脂酶 C (PLC) 信号通路的激活，并降低 AURKA 的自磷酸化水平。AURKA-IN-3 有望用于与高 AURKA 表达相关的恶性肿瘤 (例如白血病、淋巴瘤) 的研究。

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AURKA-IN-3

AURKA-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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AURKA-IN-3 相关抗体

Top Publications Citing Use of Products

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AURKA-IN-3 (Compound AL8) is an irreversible covalent Aurora kinase A (AURKA) inhibitor with an IC50 value of 23.0 nM. AURKA-IN-3 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by AURKA, and reduces the autophosphorylation level of AURKA. AURKA-IN-3 is promising for research of malignant tumors associated with high AURKA expression (e.g., leukemia, lymphoma)[1].

IC50 & Target

Aurora A

23.0 nM (IC50)

分子量

719.12

Formula

C38H28ClFN6O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AURKA-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AURKA-IN-3Aurora KinaseAURKAPLCmalignant tumorsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-175982
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